Role of Src protein tyrosine kinases in late preconditioning against myocardial infarction

Buddhadeb Dawn, Hitoshi Takano, Xian Liang Tang, Eitaro Kodani, Supratim Banerjee, Arash Rezazadeh, Yumin Qiu, Roberto Bolli

Research output: Contribution to journalArticle

Abstract

Although Src protein tyrosine kinases (PTKs) have been shown to be essential in late preconditioning (PC) against myocardial stunning, their role in triggering versus mediating late PC against myocardial infarction remains unclear. Four groups of conscious rabbits were subjected to a 30-min coronary occlusion on day 2, with or without PC ischemia on day 1. Administration of the Src PTK inhibitor lavendustin A (LD-A; 1 mg/kg iv) before the PC ischemia on day 1 (group III, n = 7) failed to block the delayed protective effect against myocardial infarction 24 h later. Late PC against infarction, however, was completely abrogated when LD-A was given 24 h after the PC ischemia, prior to the 30-min occlusion on day 2 (group IV, n = 8). We conclude that, in conscious rabbits, Src PTK activity is necessary for the mediation of late PC protection against myocardial infarction on day 2, but not for the initiation of this phenomenon on day 1. Taken together with previous studies in the setting of stunning, these findings reveal heretofore unrecognized differences in the roles of Src PTKs in late PC against stunning versus late PC against infarction.

Original languageEnglish (US)
Pages (from-to)H549-H556
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume283
Issue number2 52-2
DOIs
StatePublished - 2002

Keywords

  • Ischemia-reperfusion injury
  • Lavendustin A

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Dawn, B., Takano, H., Tang, X. L., Kodani, E., Banerjee, S., Rezazadeh, A., Qiu, Y., & Bolli, R. (2002). Role of Src protein tyrosine kinases in late preconditioning against myocardial infarction. American Journal of Physiology - Heart and Circulatory Physiology, 283(2 52-2), H549-H556. https://doi.org/10.1152/ajpheart.00873.2001