Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies

Edwin Li, Kalina Hristova

Research output: Contribution to journalReview articlepeer-review

Abstract

Receptor tyrosine kinases (RTKs) conduct biochemical signals via lateral dimerization in the plasma membrane, and their transmembrane (TM) domains play an important role in the dimerization process. Here we present two models of RTK-mediated signaling, and we discuss the role of the TM domains within the framework of these two models. We summarize findings of single-amino acid mutations in RTK TM domains that induce unregulated signaling and, as a consequence, pathological phenotypes. We review the current knowledge of pathology induction mechanisms due to these mutations, focusing on the structural and thermodynamic basis of pathogenic dimer stabilization.

Original languageEnglish (US)
Pages (from-to)6241-6251
Number of pages11
JournalBiochemistry
Volume45
Issue number20
DOIs
StatePublished - May 23 2006

ASJC Scopus subject areas

  • Biochemistry

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