Role of receptor aggregation in triggering IgE-mediated reactions

A. Kagey-Sobotka, D. W. MacGlashan, L. M. Lichtenstein

Research output: Contribution to journalReview articlepeer-review


This report briefly reviews the history of reaginic or IgE antibody, the early work done to define the antigenic signal, and the more recent work directed toward assessing the degree of IgE-receptor aggregation required for signaling or triggering mast cells or basophils. As consequences of IgE-receptor aggregation, two events occur: activation of the cells leading to mediator release, or desensitization, which leaves the mast cells and basophils intact but inert, unable to secrete via IgE interactions. Quantitative aspects of these two events will be discussed.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalFederation Proceedings
Issue number1
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Medicine(all)


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