Role of positron emission tomography imaging in Multiple Endocrine Neoplasia syndromes

Mose July, Prasanna Santhanam, Luca Giovanella, Giorgio Treglia

Research output: Contribution to journalReview article


The aim of this review was to summarize the recent developments on the role of positron emission tomography (PET) imaging using different radiopharmaceuticals in patients with multiple endocrine neoplasia (MEN) syndromes. Although most guidelines do not mention the use of PET imaging in patients with MEN syndromes, recent data seem to suggest a relevant diagnostic role of PET imaging in this setting. In particular, latest evidence has shown that somatostatin receptor PET provides a diagnostic accuracy in detecting MEN syndromes-related neuroendocrine tumours (NETs) higher than that of somatostatin receptor scintigraphy, thus influencing patient management in a significant percentage of cases. 18F-DOPA PET seems to have a potential role in detecting MEN-2-related NETs, whereas 18F-FDG PET is potentially useful in identifying aggressive NETs with poorer outcomes. More studies are needed to better define the role of different radiotracer-based PET imaging in patients with MEN syndromes.

Original languageEnglish (US)
Pages (from-to)4-9
Number of pages6
JournalClinical Physiology and Functional Imaging
Issue number1
StatePublished - Jan 1 2018
Externally publishedYes


  • multiple endocrine neoplasia syndromes
  • neuroendocrine tumours
  • PET imaging

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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