Role of oxidative stress in ED: Unraveling the molecular mechanism

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Many advances in the understanding of erection physiology and pathophysiology have been made in recent years. These advances have revealed the importance of oxidative stress and a complex interaction between oxidative stress and regulatory pathways in the penis in the development and progression of erectile dysfunction (ED) associated with various disease states. In this chapter, we present current knowledge of the pathophysiology of ED pertaining to the mechanisms of reactive oxygen species (ROS) production, the interaction between ROS-generating sources and the main regulatory pathways in the penis, the status of the antioxidant systems that reduce ROS bioavailability, and cellular targets for ROS action in vasculogenic and neurogenic ED. We further discuss a therapeutic strategy to improve erectile function in disease states by targeting specific ROS mechanisms in the penis.

Original languageEnglish (US)
Title of host publicationStudies on Men's Health and Fertility
PublisherHumana Press Inc.
Pages617-643
Number of pages27
ISBN (Electronic)9781617797767
ISBN (Print)9781617797750
DOIs
StatePublished - Jan 1 2012

Keywords

  • Erectile dysfunction
  • Molecular mechanism
  • Neurogenic ED
  • Oxidative stress
  • Penis
  • Peroxynitrite
  • Superoxide
  • Vasculogenic ED
  • Vasoconstriction
  • Vasorelaxation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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