Role of oral factor Xa inhibitors after acute coronary syndrome

Abhishek Sharma, Akash Garg, Jeffrey S. Borer, Parasuram Krishnamoorthy, Jalaj Garg, Carl J. Lavie, Armin Arbab-Zadeh, Debabrata Mukherjee, Hasan Ahmad, Edgar Lichstein

Research output: Contribution to journalArticle

Abstract

Despite an early invasive strategy and the use of dual antiplatelet therapy, patients with acute coronary syndrome (ACS) continue to be at substantial risk for recurrent ischemic events. It is believed that this risk is, at least in part, due to an intrinsic coagulation pathway that remains activated for a prolonged period after ACS. Earlier studies using warfarin showed a reduction in ischemic events, but the overall benefits were offset by increased bleeding complications. Recently, there has been increased interest in the potential role of new oral anticoagulants, some of which target factor Xa, after ACS. Factor Xa is important for the coagulation pathway and also plays a role in cellular proliferation and inflammation. It may thus be an attractive target for therapeutic intervention in ACS. Recently, various oral factor Xa inhibitors have been studied as potential treatment options for ACS. This review will focus on currently available data to evaluate the possible role of factor Xa inhibitors in the management of patients with ACS.

Original languageEnglish (US)
Pages (from-to)224-232
Number of pages9
JournalCardiology (Switzerland)
Volume129
Issue number4
DOIs
StatePublished - Apr 16 2014

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Keywords

  • Acute coronary syndrome
  • Coagulation pathway
  • Factor Xa

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Sharma, A., Garg, A., Borer, J. S., Krishnamoorthy, P., Garg, J., Lavie, C. J., Arbab-Zadeh, A., Mukherjee, D., Ahmad, H., & Lichstein, E. (2014). Role of oral factor Xa inhibitors after acute coronary syndrome. Cardiology (Switzerland), 129(4), 224-232. https://doi.org/10.1159/000368747