Role of no in neurodegeneration

Research output: Chapter in Book/Report/Conference proceedingChapter


Nitric oxide (NO) is an unprecedented biological messenger molecule. NO is synthesized by the enzymes NO synthases, that catalyze the essential amino acid l-arginine into NO and l-citrulline. In the central nervous system, NO is an unusual neuronal messenger molecule; due to its small size and ability to move through lipids, NO reaches its targets through diffusion. NO forms covalent and noncovalent linkages with protein and nonprotein targets and is involved in a wide range of physiological and pathophysiological actions. NO has been linked to the development and progression of neural injury in stroke, Parkinson's disease, and Alzheimer's disease.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages6
ISBN (Print)9780080450469
StatePublished - Jan 1 2009


  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Excitotoxicity
  • Ischemia
  • Nitric oxide
  • Nitric oxide synthase
  • Parkinson's disease
  • Peroxynitrite
  • Poly(ADP-ribose) polymerase
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)


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