Role of nitric oxide scavenging in peripheral vasoconstrictor response to bovine ββ crosslinked hemoglobin

J. A. Ulatowski, R. C. Koehler, T. Nishikawa, R. J. Traystman, E. Bucci

Research output: Contribution to journalConference article

Abstract

Using pentobarbital cats, the authors tested whether administration of the nitrogen oxide (NO) synthase inhibitor, L-nitro-L-arginine methyl ester (L-NAME), produced peripheral vasoconstriction after isovolemic exchange transfusion with hemoglobin (n = 8) to the same extent as occurs with L-NAME infusion in time controls (n = 8), and in controls matched for reduced hematocrit (17%) with albumin transfusion (n = 8). Hemoglobin exchange transfusion resulted in an increase in mean arterial pressure and there was no further increase after L-NAME. The lack of intestinal and renal vasoconstriction to L-NAME after hemoglobin transfusion is best explained by hemoglobin scavenging of NO prior to NO synthase inhibition.

Original languageEnglish (US)
Pages (from-to)A173
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1 1994
EventProceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA
Duration: Jul 24 1994Jul 27 1994

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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