Role of nitric oxide in Parkinson's disease

Li Zhang; Valina L. Dawson; Ted M. Dawson

doi:10.1016/j.pharmthera.2005.05.007

Role of nitric oxide in Parkinson's disease

Li Zhang, Valina L. Dawson, Ted M. Dawson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

123 Scopus citations

Abstract

As a signal molecule, nitric oxide (NO) plays an important role in a variety of signal transduction pathways that are crucial for maintaining the physiologic functions of vascular, respiratory, immune, muscular, and nervous systems. NO and its derivatives are also involved in the pathogenic processes in various types of diseases including, but not limited to, neurodegenerative disorders. Although the molecular mechanisms of how NO contributes to diseases are not completely understood, studies have shown that NO may cause neuronal injury and death by mediation of excitotoxicity, damage of DNA, and/or modification of proteins. Understanding the pathogenic mechanisms of NO and its role in Parkinson's disease (PD) and other neurodegenerative diseases may help to develop novel neuroprotective therapies for these diseases.

Original language	English (US)
Pages (from-to)	33-41
Number of pages	9
Journal	Pharmacology and Therapeutics
Volume	109
Issue number	1-2
DOIs	https://doi.org/10.1016/j.pharmthera.2005.05.007
State	Published - Jan 2006

Keywords

Excitotoxicity
Nitric oxide
Oxidative stress
Parkinson's disease

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1016/j.pharmthera.2005.05.007

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title = "Role of nitric oxide in Parkinson's disease",

abstract = "As a signal molecule, nitric oxide (NO) plays an important role in a variety of signal transduction pathways that are crucial for maintaining the physiologic functions of vascular, respiratory, immune, muscular, and nervous systems. NO and its derivatives are also involved in the pathogenic processes in various types of diseases including, but not limited to, neurodegenerative disorders. Although the molecular mechanisms of how NO contributes to diseases are not completely understood, studies have shown that NO may cause neuronal injury and death by mediation of excitotoxicity, damage of DNA, and/or modification of proteins. Understanding the pathogenic mechanisms of NO and its role in Parkinson's disease (PD) and other neurodegenerative diseases may help to develop novel neuroprotective therapies for these diseases.",

keywords = "Excitotoxicity, Nitric oxide, Oxidative stress, Parkinson's disease",

author = "Li Zhang and Dawson, {Valina L.} and Dawson, {Ted M.}",

note = "Funding Information: This work was support by grants from the USPHS NS38377, NS047565, NS48206, the Lee Martin Trust, and the Sylvia Nachlas Trust. L.Z. is a recipient of the Veola Kerr Postdoctoral Fellowship from the Parkinson's Disease Foundation. T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. Under a licensing agreement between Guilford Pharmaceuticals and the Johns Hopkins University, Dr. Dawson is entitled to a share of the royalty received by the University from Guilford Pharmaceuticals. The terms of this arrangement are being managed by the Johns Hopkins University in accordance with its conflict of interest policies.",

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AU - Dawson, Valina L.

AU - Dawson, Ted M.

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PY - 2006/1

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N2 - As a signal molecule, nitric oxide (NO) plays an important role in a variety of signal transduction pathways that are crucial for maintaining the physiologic functions of vascular, respiratory, immune, muscular, and nervous systems. NO and its derivatives are also involved in the pathogenic processes in various types of diseases including, but not limited to, neurodegenerative disorders. Although the molecular mechanisms of how NO contributes to diseases are not completely understood, studies have shown that NO may cause neuronal injury and death by mediation of excitotoxicity, damage of DNA, and/or modification of proteins. Understanding the pathogenic mechanisms of NO and its role in Parkinson's disease (PD) and other neurodegenerative diseases may help to develop novel neuroprotective therapies for these diseases.

AB - As a signal molecule, nitric oxide (NO) plays an important role in a variety of signal transduction pathways that are crucial for maintaining the physiologic functions of vascular, respiratory, immune, muscular, and nervous systems. NO and its derivatives are also involved in the pathogenic processes in various types of diseases including, but not limited to, neurodegenerative disorders. Although the molecular mechanisms of how NO contributes to diseases are not completely understood, studies have shown that NO may cause neuronal injury and death by mediation of excitotoxicity, damage of DNA, and/or modification of proteins. Understanding the pathogenic mechanisms of NO and its role in Parkinson's disease (PD) and other neurodegenerative diseases may help to develop novel neuroprotective therapies for these diseases.

KW - Excitotoxicity

KW - Nitric oxide

KW - Oxidative stress

KW - Parkinson's disease

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Role of nitric oxide in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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