Role of NF-κB in the anti-inflammatory effects of tocotrienols

Mary Kaileh, Ranjan Sen

Research output: Contribution to journalArticle

Abstract

The NF-κB family of transcription factors regulates genes that are critical for inflammation and immunity. In most cells, NF-κB function is induced upon activation of cells by various stimuli. However, constitutive NF-κB activity is anequally important aspect of NF-κB function that is particularly relevant to chronic inflammation and cancer. Here, we provide a brief overview of NF-κB biology and discuss the role of NF-κB in mediating the anti-inflammatory effects of tocotrienols The NF-κB family of transcription factors is a central player in the regulation of inflammation and immune responses. Consequently, NF-κB dysregulation has been implicated in diverse human pathologies ranging from autoimmune diseases to cancers. Additionally, there is considerable interest in the contribution of NF-κB- mediated chronic inflammation in aging. Because NF-κB-dependent gene regulation is important in virtually all mammalian cell types, it is critical to keep in mind some basic features of its functions when considering interventional therapeutics.

Original languageEnglish (US)
JournalJournal of the American College of Nutrition
Volume29
Issue numberSUPPL. 1
StatePublished - 2010
Externally publishedYes

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Keywords

  • Inflammation
  • NF-κB
  • Tocotrienols

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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