Role of neurodevelopment involved genes in psychiatric comorbidities and modulation of inflammatory processes in Alzheimer's disease

Porcelli Stefano, Crisafulli Concetta, Donato Luigi, Calabrò Marco, Antonis Politis, Liappas Ioannis, Albani Diego, Atti Anna Rita, Salfi Raffaele, Raimondi Ilaria, Forloni Gianluigi, Papadimitriou George N., De Ronchi Diana, Serretti Alessandro

Research output: Contribution to journalArticle

Abstract

Introduction With the increase of the population's average age, Alzheimer's disease (AD) is becoming one of the most disabling diseases worldwide. Recently, neurodevelopment processes have been involved in the AD etiopathogenesis. Genetic studies in this field could contribute to our knowledge and suggest new molecular targets for possible treatments. Methods Our primary aim was to investigate the associations among single nucleotide polymorphisms (SNPs) within neurodevelopment related genes (BDNF, ST8SIA2, C15orf32, NCAPG2, ESYT2, WDR60, LOC154822, VIPR2, GSK3B, NR1I2, ZNF804A, SP4) and AD. A number of exploratory analyses was also performed to evaluate the associations with the presence of behavioral and psychiatric symptoms of dementia (BPSD), as well as with variations in hematological parameters. Two independent samples were investigated, one of 228 Greek subjects and one sample of 229 Italian subjects, including 156 Alzheimer's Disease patients CE patients and 301 healthy controls. All patients were affected by late onset AD (LOAD). Results None of the analyzed SNPs was associated with AD in our samples. In the exploratory analyses, several genetic variants were associated with inflammation parameters in the Greek sample and in the merged one, suggesting a relationship among these genes and the modulation of inflammation and the immune response. Other exploratory analyses showed associations among several SNPs and psychiatric symptomatology in the Greek sample, suggesting a possible modulation of these variants on psychiatric comorbidities in AD. Conclusions Although we failed to find a direct relationship between AD and the genetic variants investigated, possible connections with inflammation and psychiatric symptoms were suggested.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalJournal of the Neurological Sciences
Volume370
DOIs
StatePublished - Nov 15 2016
Externally publishedYes

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Psychiatry
Comorbidity
Alzheimer Disease
Genes
Single Nucleotide Polymorphism
Inflammation
Behavioral Symptoms
Brain-Derived Neurotrophic Factor
Dementia
Population

Keywords

  • Alzheimer's disease
  • Depression
  • Genetics
  • Inflammation
  • Neurodevelopment
  • Psychosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Role of neurodevelopment involved genes in psychiatric comorbidities and modulation of inflammatory processes in Alzheimer's disease. / Stefano, Porcelli; Concetta, Crisafulli; Luigi, Donato; Marco, Calabrò; Politis, Antonis; Ioannis, Liappas; Diego, Albani; Anna Rita, Atti; Raffaele, Salfi; Ilaria, Raimondi; Gianluigi, Forloni; George N., Papadimitriou; Diana, De Ronchi; Alessandro, Serretti.

In: Journal of the Neurological Sciences, Vol. 370, 15.11.2016, p. 162-166.

Research output: Contribution to journalArticle

Stefano, P, Concetta, C, Luigi, D, Marco, C, Politis, A, Ioannis, L, Diego, A, Anna Rita, A, Raffaele, S, Ilaria, R, Gianluigi, F, George N., P, Diana, DR & Alessandro, S 2016, 'Role of neurodevelopment involved genes in psychiatric comorbidities and modulation of inflammatory processes in Alzheimer's disease', Journal of the Neurological Sciences, vol. 370, pp. 162-166. https://doi.org/10.1016/j.jns.2016.09.053
Stefano, Porcelli ; Concetta, Crisafulli ; Luigi, Donato ; Marco, Calabrò ; Politis, Antonis ; Ioannis, Liappas ; Diego, Albani ; Anna Rita, Atti ; Raffaele, Salfi ; Ilaria, Raimondi ; Gianluigi, Forloni ; George N., Papadimitriou ; Diana, De Ronchi ; Alessandro, Serretti. / Role of neurodevelopment involved genes in psychiatric comorbidities and modulation of inflammatory processes in Alzheimer's disease. In: Journal of the Neurological Sciences. 2016 ; Vol. 370. pp. 162-166.
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abstract = "Introduction With the increase of the population's average age, Alzheimer's disease (AD) is becoming one of the most disabling diseases worldwide. Recently, neurodevelopment processes have been involved in the AD etiopathogenesis. Genetic studies in this field could contribute to our knowledge and suggest new molecular targets for possible treatments. Methods Our primary aim was to investigate the associations among single nucleotide polymorphisms (SNPs) within neurodevelopment related genes (BDNF, ST8SIA2, C15orf32, NCAPG2, ESYT2, WDR60, LOC154822, VIPR2, GSK3B, NR1I2, ZNF804A, SP4) and AD. A number of exploratory analyses was also performed to evaluate the associations with the presence of behavioral and psychiatric symptoms of dementia (BPSD), as well as with variations in hematological parameters. Two independent samples were investigated, one of 228 Greek subjects and one sample of 229 Italian subjects, including 156 Alzheimer's Disease patients CE patients and 301 healthy controls. All patients were affected by late onset AD (LOAD). Results None of the analyzed SNPs was associated with AD in our samples. In the exploratory analyses, several genetic variants were associated with inflammation parameters in the Greek sample and in the merged one, suggesting a relationship among these genes and the modulation of inflammation and the immune response. Other exploratory analyses showed associations among several SNPs and psychiatric symptomatology in the Greek sample, suggesting a possible modulation of these variants on psychiatric comorbidities in AD. Conclusions Although we failed to find a direct relationship between AD and the genetic variants investigated, possible connections with inflammation and psychiatric symptoms were suggested.",
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T1 - Role of neurodevelopment involved genes in psychiatric comorbidities and modulation of inflammatory processes in Alzheimer's disease

AU - Stefano, Porcelli

AU - Concetta, Crisafulli

AU - Luigi, Donato

AU - Marco, Calabrò

AU - Politis, Antonis

AU - Ioannis, Liappas

AU - Diego, Albani

AU - Anna Rita, Atti

AU - Raffaele, Salfi

AU - Ilaria, Raimondi

AU - Gianluigi, Forloni

AU - George N., Papadimitriou

AU - Diana, De Ronchi

AU - Alessandro, Serretti

PY - 2016/11/15

Y1 - 2016/11/15

N2 - Introduction With the increase of the population's average age, Alzheimer's disease (AD) is becoming one of the most disabling diseases worldwide. Recently, neurodevelopment processes have been involved in the AD etiopathogenesis. Genetic studies in this field could contribute to our knowledge and suggest new molecular targets for possible treatments. Methods Our primary aim was to investigate the associations among single nucleotide polymorphisms (SNPs) within neurodevelopment related genes (BDNF, ST8SIA2, C15orf32, NCAPG2, ESYT2, WDR60, LOC154822, VIPR2, GSK3B, NR1I2, ZNF804A, SP4) and AD. A number of exploratory analyses was also performed to evaluate the associations with the presence of behavioral and psychiatric symptoms of dementia (BPSD), as well as with variations in hematological parameters. Two independent samples were investigated, one of 228 Greek subjects and one sample of 229 Italian subjects, including 156 Alzheimer's Disease patients CE patients and 301 healthy controls. All patients were affected by late onset AD (LOAD). Results None of the analyzed SNPs was associated with AD in our samples. In the exploratory analyses, several genetic variants were associated with inflammation parameters in the Greek sample and in the merged one, suggesting a relationship among these genes and the modulation of inflammation and the immune response. Other exploratory analyses showed associations among several SNPs and psychiatric symptomatology in the Greek sample, suggesting a possible modulation of these variants on psychiatric comorbidities in AD. Conclusions Although we failed to find a direct relationship between AD and the genetic variants investigated, possible connections with inflammation and psychiatric symptoms were suggested.

AB - Introduction With the increase of the population's average age, Alzheimer's disease (AD) is becoming one of the most disabling diseases worldwide. Recently, neurodevelopment processes have been involved in the AD etiopathogenesis. Genetic studies in this field could contribute to our knowledge and suggest new molecular targets for possible treatments. Methods Our primary aim was to investigate the associations among single nucleotide polymorphisms (SNPs) within neurodevelopment related genes (BDNF, ST8SIA2, C15orf32, NCAPG2, ESYT2, WDR60, LOC154822, VIPR2, GSK3B, NR1I2, ZNF804A, SP4) and AD. A number of exploratory analyses was also performed to evaluate the associations with the presence of behavioral and psychiatric symptoms of dementia (BPSD), as well as with variations in hematological parameters. Two independent samples were investigated, one of 228 Greek subjects and one sample of 229 Italian subjects, including 156 Alzheimer's Disease patients CE patients and 301 healthy controls. All patients were affected by late onset AD (LOAD). Results None of the analyzed SNPs was associated with AD in our samples. In the exploratory analyses, several genetic variants were associated with inflammation parameters in the Greek sample and in the merged one, suggesting a relationship among these genes and the modulation of inflammation and the immune response. Other exploratory analyses showed associations among several SNPs and psychiatric symptomatology in the Greek sample, suggesting a possible modulation of these variants on psychiatric comorbidities in AD. Conclusions Although we failed to find a direct relationship between AD and the genetic variants investigated, possible connections with inflammation and psychiatric symptoms were suggested.

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KW - Depression

KW - Genetics

KW - Inflammation

KW - Neurodevelopment

KW - Psychosis

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