Role of natural killer cells in the generation of influenza virus-specific cytotoxic T cells

Ferdynand J. Kos, Edgar G. Engleman

Research output: Contribution to journalArticle

Abstract

Recently we reported that natural killer (NK) cells are critical accessory cells required for the differentiation of alloantigen-stimulated CD8+ T cells into effector cytotoxic T lymphocytes (CTL) in vitro. In this study we provide evidence that NK cells are also required for the generation of influenza virus-specific CTL. Depletion of NK cells from responder human peripheral blood mononuclear cells or mouse splenocytes abolished the induction of influenza A virus-specific CTL under culture conditions. Treatment of C57BL/6 mice with the NK cell-depleting NK1.1 monoclonal antibody (mAb) before primary or secondary immunization with influenza A virus abrogated the capacity of CTL precursors to differentiate into influenza virus-specific CTL effectors in vivo. These results extend our previous findings and demonstrate that NK cells critically influence the induction of antigen-specific CTL, both in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCellular Immunology
Volume173
Issue number1
DOIs
StatePublished - Oct 10 1996

ASJC Scopus subject areas

  • Immunology

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