Role of myeloid-derived suppressor cells and regulatory t-cells in the tuberculous granuloma

Laurene S. Cheung, Geetha Srikrishna, William R. Bishai

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In the course of Mycobacterium tuberculosis (M. tb) infection, while a robust immune response is required for containment and clearance of the pathogen, immune-mediated tissue damage may also occur. Immune suppressive cells, such as regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) are recruited to the site of infection, but in the process of controlling immune responses can promote pathogen survival. Tregs are known to be elevated in tuberculosis (TB) patients with active disease and studies in animal models demonstrate that Tregs inhibit effector T cell function through multiple mechanisms during M. tb infection (Guyot-Revol et al., Am J Respir Crit Care Med 173:803-10, 2006). More recently, increased levels of MDSCs have been found in patients with active TB and although less is known about their role in infection, it has become clear that MDSCs are very effective in suppressing T cell responses in tumors (El Daker et al., PLoS One 10:e0123772, 2015). In this chapter, we will give a brief overview of the early immune response to M. tb. infection and the host's attempt to contain infection through the formation of granulomas in the lung. We will then review the function of MDSCs and Tregs and what is known about their role during TB infection. Finally, we will discuss currently available drugs that can target these cell populations and their potential use for the treatment of TB.

Original languageEnglish (US)
Title of host publicationTuberculosis Host-Pathogen Interactions
PublisherSpringer International Publishing
Pages63-93
Number of pages31
ISBN (Electronic)9783030253813
ISBN (Print)9783030253806
DOIs
StatePublished - Sep 10 2019

Keywords

  • Effector T cells
  • Granuloma
  • Host-directed therapy
  • Immune checkpoint inhibition
  • Immune suppression
  • Immunotherapy
  • Inflammation
  • Myeloid-derived suppressor cells
  • Regulatory T cells
  • Tuberculosis

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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