Role of melanotransferrin in iron metabolism: Studies using targeted gene disruption in vivo

Eric O. Sekyere, Louise L. Dunn, Yohan Suryo Rahmanto, Des R. Richardson

Research output: Contribution to journalArticle

Abstract

Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation. Considering the vital role of Fe in many metabolic pathways, such as DNA and heme synthesis, it is important to understand the function of MTf. To define this, a MTf knockout (MTf-/-) mouse was generated through targeted disruption of the MTf gene. The MTf-/- mice were viable and fertile and developed normally, with no morphologic or histologic abnormalities. Assessment of Fe indices, tissue Fe levels, hematology, and serum chemistry parameters demonstrated no differences between MTf-/- and wild-type (MTf+/+) mice, suggesting MTf was not essential for Fe metabolism.

Original languageEnglish (US)
Pages (from-to)2599-2601
Number of pages3
JournalBlood
Volume107
Issue number7
DOIs
StatePublished - Apr 1 2006

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Sekyere, E. O., Dunn, L. L., Rahmanto, Y. S., & Richardson, D. R. (2006). Role of melanotransferrin in iron metabolism: Studies using targeted gene disruption in vivo. Blood, 107(7), 2599-2601. https://doi.org/10.1182/blood-2005-10-4174