TY - JOUR
T1 - Role of melanotransferrin in iron metabolism
T2 - Studies using targeted gene disruption in vivo
AU - Sekyere, Eric O.
AU - Dunn, Louise L.
AU - Rahmanto, Yohan Suryo
AU - Richardson, Des R.
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation. Considering the vital role of Fe in many metabolic pathways, such as DNA and heme synthesis, it is important to understand the function of MTf. To define this, a MTf knockout (MTf-/-) mouse was generated through targeted disruption of the MTf gene. The MTf-/- mice were viable and fertile and developed normally, with no morphologic or histologic abnormalities. Assessment of Fe indices, tissue Fe levels, hematology, and serum chemistry parameters demonstrated no differences between MTf-/- and wild-type (MTf+/+) mice, suggesting MTf was not essential for Fe metabolism.
AB - Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation. Considering the vital role of Fe in many metabolic pathways, such as DNA and heme synthesis, it is important to understand the function of MTf. To define this, a MTf knockout (MTf-/-) mouse was generated through targeted disruption of the MTf gene. The MTf-/- mice were viable and fertile and developed normally, with no morphologic or histologic abnormalities. Assessment of Fe indices, tissue Fe levels, hematology, and serum chemistry parameters demonstrated no differences between MTf-/- and wild-type (MTf+/+) mice, suggesting MTf was not essential for Fe metabolism.
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U2 - 10.1182/blood-2005-10-4174
DO - 10.1182/blood-2005-10-4174
M3 - Article
C2 - 16291590
AN - SCOPUS:33645528381
SN - 0006-4971
VL - 107
SP - 2599
EP - 2601
JO - Blood
JF - Blood
IS - 7
ER -