Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference

Ashley M. Blouin, Sungho Han, Anne M. Pearce, Kai Lun Cheng, Jong Ah J. Lee, Alexander W. Johnson, Chuansong Wang, Matthew J. During, Peter C. Holland, Yavin Shaham, Jay M. Baraban, Irving M. Reti

Research output: Contribution to journalArticlepeer-review

Abstract

Narp knockout (KO) mice demonstrate an impaired extinction of morphine conditioned place preference (CPP). Because the medial prefrontal cortex (mPFC) has been implicated in extinction learning, we tested whether Narp cells in this region play a role in the extinction of morphine CPP. We found that intracranial injections of adenoassociated virus (AAV) expressing wild-type (WT) Narp into the mPFC of Narp KO mice rescued the extinction and the injection of AAV expressing a dominant negative form of Narp (NarpN) into the mPFC of WT mice impaired the extinction of morphine CPP. These findings suggest that Narp in the mPFC mediates the extinction of morphine CPP.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalLearning and Memory
Volume20
Issue number2
DOIs
StatePublished - Feb 2013

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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