Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury

Sangmin Jeon, Mithilesh Kumar Jha, Jiyeon Ock, Jungwan Seo, Myungwon Jin, Heejung Cho, Won Ha Lee, Kyoungho Suk

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In the central nervous system, the role of LCN2 as a chemokine inducer has been previously reported. Results: Peripheral nerve injury increased LCN2 expression. Lcn2 deficiency attenuated pain hypersensitivity, microglial activation, and chemokine production. Chemokine expression and pain behavior were induced by LCN2. Conclusion: The LCN2-chemokine axis plays a critical role in the pathogenesis of neuropathic pain. Significance: LCN2 can be targeted for treatment of neuropathic pain.

Original languageEnglish (US)
Pages (from-to)24116-24127
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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