Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury

Sang-Min Jeon, Mithilesh Kumar Jha, Jiyeon Ock, Jungwan Seo, Myungwon Jin, Heejung Cho, Won Ha Lee, Kyoungho Suk

Research output: Contribution to journalArticle

Abstract

Background: In the central nervous system, the role of LCN2 as a chemokine inducer has been previously reported. Results: Peripheral nerve injury increased LCN2 expression. Lcn2 deficiency attenuated pain hypersensitivity, microglial activation, and chemokine production. Chemokine expression and pain behavior were induced by LCN2. Conclusion: The LCN2-chemokine axis plays a critical role in the pathogenesis of neuropathic pain. Significance: LCN2 can be targeted for treatment of neuropathic pain.

Original languageEnglish (US)
Pages (from-to)24116-24127
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
Publication statusPublished - Aug 16 2013
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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