Role of lipids in urinary stones

Studies of calcium oxalate precipitation at phospholipid langmuir monolayers

Daniel R. Talham, Renal Backov, Isa O. Benitez, Denise M. Sharbaugh, Scott Whipps, Saeed R. Khan

Research output: Contribution to journalArticle

Abstract

This article reviews the authors' experiments on calcium oxalate growth at lipid monolayers. Calcium oxalate is the principal mineral component of most urinary stones. Membrane constituents associate either actively or passively with calcific minerals during stone formation, and it has been proposed that lipid assemblies play a significant role, possibly providing sites for the initial nucleation event. Langmuir monolayers allow systematic studies of the heterogeneous precipitation of calcium oxalate at lipid assemblies. The influences of the chemical identity of the lipid headgroup, the organization of the monolayer, and the presence of heterogeneities and phase boundaries within the monolayer have been explored.

Original languageEnglish (US)
Pages (from-to)2450-2456
Number of pages7
JournalLangmuir
Volume22
Issue number6
DOIs
StatePublished - Mar 14 2006
Externally publishedYes

Fingerprint

Calcium Oxalate
monomolecular films
Phospholipids
oxalates
Lipids
lipids
calcium
Calcium
Monolayers
rocks
assemblies
Minerals
minerals
Phase boundaries
Nucleation
nucleation
membranes
Membranes
Experiments

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Talham, D. R., Backov, R., Benitez, I. O., Sharbaugh, D. M., Whipps, S., & Khan, S. R. (2006). Role of lipids in urinary stones: Studies of calcium oxalate precipitation at phospholipid langmuir monolayers. Langmuir, 22(6), 2450-2456. https://doi.org/10.1021/la052503u

Role of lipids in urinary stones : Studies of calcium oxalate precipitation at phospholipid langmuir monolayers. / Talham, Daniel R.; Backov, Renal; Benitez, Isa O.; Sharbaugh, Denise M.; Whipps, Scott; Khan, Saeed R.

In: Langmuir, Vol. 22, No. 6, 14.03.2006, p. 2450-2456.

Research output: Contribution to journalArticle

Talham, DR, Backov, R, Benitez, IO, Sharbaugh, DM, Whipps, S & Khan, SR 2006, 'Role of lipids in urinary stones: Studies of calcium oxalate precipitation at phospholipid langmuir monolayers', Langmuir, vol. 22, no. 6, pp. 2450-2456. https://doi.org/10.1021/la052503u
Talham, Daniel R. ; Backov, Renal ; Benitez, Isa O. ; Sharbaugh, Denise M. ; Whipps, Scott ; Khan, Saeed R. / Role of lipids in urinary stones : Studies of calcium oxalate precipitation at phospholipid langmuir monolayers. In: Langmuir. 2006 ; Vol. 22, No. 6. pp. 2450-2456.
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