Role of inflammation in virus pathogenesis during pregnancy

Anna Chudnovets, Jin Liu, Harish Narasimhan, Yang Liu, Irina Burd

Research output: Contribution to journalReview articlepeer-review

Abstract

Viral infections during pregnancy lead to a spectrum of maternal and fetal outcomes, ranging from asymptomatic disease to more critical conditions presenting with severe maternal morbidity, stillbirth, preterm birth, intrauterine growth restriction, and fetal congenital anomalies, either apparent at birth or later in life. In this article, we review the pathogenesis of several viral infections that are particularly relevant in the context of pregnancy and intrauterine inflammation. Understanding the diverse mechanisms employed by viral pathogens as well as the repertoire of immune responses induced in the mother may help to establish novel therapeutic options to attenuate changes in the maternal-fetal interface and prevent adverse pregnancy outcomes.

Original languageEnglish (US)
Article numbere01381-19
JournalJournal of virology
Volume95
Issue number2
DOIs
StatePublished - Jan 2021

Keywords

  • Inflammation
  • Pregnancy
  • Viral infection

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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