Role of Immune Cells in Acute Kidney Injury and Repair

Sul A. Lee; Sanjeev Noel; Mohanraj Sadasivam; Abdel R.A. Hamad; Hamid Rabb

doi:10.1159/000477181

Role of Immune Cells in Acute Kidney Injury and Repair

Sul A. Lee, Sanjeev Noel, Mohanraj Sadasivam, Abdel R.A. Hamad, Hamid Rabb

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Acute kidney injury (AKI) is a significant problem in both native and transplant kidneys. There have been significant advances in understanding the role of immune cells in the early injury and repair from AKI. In this brief review, we aim to update information on the pathophysiologic impact of various immune cells in AKI, with special emphasis on repair. An improved understanding of the AKI immunopathology will lead to new therapies that prevent AKI, accelerate repair, and prevent the progression of AKI to chronic kidney disease.

Original language	English (US)
Pages (from-to)	282-286
Number of pages	5
Journal	Nephron
Volume	137
Issue number	4
DOIs	https://doi.org/10.1159/000477181
State	Published - Nov 1 2017

ASJC Scopus subject areas

Physiology
Nephrology
Physiology (medical)
Urology

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abstract = "Acute kidney injury (AKI) is a significant problem in both native and transplant kidneys. There have been significant advances in understanding the role of immune cells in the early injury and repair from AKI. In this brief review, we aim to update information on the pathophysiologic impact of various immune cells in AKI, with special emphasis on repair. An improved understanding of the AKI immunopathology will lead to new therapies that prevent AKI, accelerate repair, and prevent the progression of AKI to chronic kidney disease.",

author = "Lee, {Sul A.} and Sanjeev Noel and Mohanraj Sadasivam and Hamad, {Abdel R.A.} and Hamid Rabb",

note = "Funding Information: Contribution from the AKI and CRRT 2017 Symposium at the 22nd International Conference on Advances in Critical Care Nephrology, Manchester Grand Hyatt, San Diego, CA, USA, March 7–10, 2017. This symposium was supported in part by the NIDDK funded University of Alabama at Birmingham-University of California San Diego O{\textquoteright}Brien Center for Acute Kidney Injury Research (P30 DK079337). Publisher Copyright: {\textcopyright} 2017 S. Karger AG, Basel. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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AU - Rabb, Hamid

N1 - Funding Information: Contribution from the AKI and CRRT 2017 Symposium at the 22nd International Conference on Advances in Critical Care Nephrology, Manchester Grand Hyatt, San Diego, CA, USA, March 7–10, 2017. This symposium was supported in part by the NIDDK funded University of Alabama at Birmingham-University of California San Diego O’Brien Center for Acute Kidney Injury Research (P30 DK079337). Publisher Copyright: © 2017 S. Karger AG, Basel. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

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N2 - Acute kidney injury (AKI) is a significant problem in both native and transplant kidneys. There have been significant advances in understanding the role of immune cells in the early injury and repair from AKI. In this brief review, we aim to update information on the pathophysiologic impact of various immune cells in AKI, with special emphasis on repair. An improved understanding of the AKI immunopathology will lead to new therapies that prevent AKI, accelerate repair, and prevent the progression of AKI to chronic kidney disease.

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Role of Immune Cells in Acute Kidney Injury and Repair

Abstract

ASJC Scopus subject areas

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