Role of Immune and Autoimmune Dysfunction in Schizophrenia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, we review data in support of the concept that immune system dysregulation is the most plausible explanation that reconciles gene by environmental interactions in schizophrenia. Early investigations of this topic demonstrated aspects of aberrant activation of humoral immunity, including autoimmunity, associated with schizophrenia, whereas current research efforts have expanded this theme to include elements of innate immunity. Advances in our understanding of inflammation and molecules of both the adaptive and innate immune system and their functional roles in standard brain physiology provide an important context by which schizophrenia might arise as the result of the coupling of immune and neurodevelopmental dysregulation.

Original languageEnglish (US)
Title of host publicationHandbook of Behavioral Neuroscience
PublisherElsevier B.V.
Pages501-516
Number of pages16
Volume23
DOIs
StatePublished - 2016

Publication series

NameHandbook of Behavioral Neuroscience
Volume23
ISSN (Print)15697339

Keywords

  • Autoantigens
  • Endothelial
  • Gastrointestinal
  • Pathogens
  • Prenatal

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

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  • Cite this

    Severance, E. G., & Yolken, R. H. (2016). Role of Immune and Autoimmune Dysfunction in Schizophrenia. In Handbook of Behavioral Neuroscience (Vol. 23, pp. 501-516). (Handbook of Behavioral Neuroscience; Vol. 23). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-800981-9.00029-8