Role of immediate early gene expression in cortical morphogenesis and plasticity.

Katrin I. Andreasson, Walter E. Kaufmann

    Research output: Contribution to journalArticle

    Abstract

    During the development of the central nervous system, there is a fundamental requirement for synaptic activity in transforming immature neuronal connections into organized functional circuits (Katz 1996). The molecular mechanisms underlying activity-dependent adaptive changes in neurons are believed to involve regulated cascades of gene expression. Immediate early genes (IEGs) comprise the initial cascade of gene expression responsible for initiating the process of stimulus-induced adaptive change, and were identified initially as transcription factors that were regulated in brain by excitatory synaptic activity. More recently, a class of neuronal immediate early genes has been identified that encodes growth factors, signaling molecules, extracellular matrix and adhesion proteins, and cytoskeletal proteins that are rapidly and transiently expressed in response to glutamatergic neurotransmission. This review focuses on the neuronal immediate early gene (nIEG) response, in particular, the class of "effector" immediate early gene proteins that may directly modify neuronal and synaptic function.

    Original languageEnglish (US)
    Pages (from-to)113-137
    Number of pages25
    JournalResults and Problems in Cell Differentiation
    Volume39
    StatePublished - 2002

    Fingerprint

    Immediate-Early Genes
    Morphogenesis
    Gene Expression
    Immediate-Early Proteins
    Cytoskeletal Proteins
    Extracellular Matrix Proteins
    Synaptic Transmission
    Intercellular Signaling Peptides and Proteins
    Transcription Factors
    Central Nervous System
    Neurons
    Brain
    Proteins

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

    Cite this

    Role of immediate early gene expression in cortical morphogenesis and plasticity. / Andreasson, Katrin I.; Kaufmann, Walter E.

    In: Results and Problems in Cell Differentiation, Vol. 39, 2002, p. 113-137.

    Research output: Contribution to journalArticle

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