TY - JOUR
T1 - Role of Imaging in Cardiac Stem Cell Therapy
AU - Beeres, Saskia L.M.A.
AU - Bengel, Frank Michael
AU - Bartunek, Jozef
AU - Atsma, Douwe E.
AU - Hill, Jonathan M.
AU - Vanderheyden, Marc
AU - Penicka, Martin
AU - Schalij, Martin J.
AU - Wijns, William
AU - Bax, Jeroen J.
PY - 2007/3/20
Y1 - 2007/3/20
N2 - Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases. Preclinical and a number of early phase human studies suggested that cell therapy may augment perfusion and increase myocardial contractility. The rapid translation into clinical trials has left many issues unresolved, and emphasizes the need for specific techniques to visualize the mechanisms involved. Furthermore, the clinical efficacy of cell therapy remains to be proven. Imaging allows for in vivo tracking of cells and can provide a better understanding in the evaluation of the functional effects of cell-based therapies. In this review, a summary of the most promising imaging techniques for cell tracking is provided. Among these are direct labeling of cells with super-paramagnetic agents, radionuclides, and the use of reporter genes for imaging of transplanted cells. In addition, a comprehensive summary is provided of the currently available studies investigating a cell therapy-related effect on left ventricular function, myocardial perfusion, scar tissue, and myocardial viability.
AB - Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases. Preclinical and a number of early phase human studies suggested that cell therapy may augment perfusion and increase myocardial contractility. The rapid translation into clinical trials has left many issues unresolved, and emphasizes the need for specific techniques to visualize the mechanisms involved. Furthermore, the clinical efficacy of cell therapy remains to be proven. Imaging allows for in vivo tracking of cells and can provide a better understanding in the evaluation of the functional effects of cell-based therapies. In this review, a summary of the most promising imaging techniques for cell tracking is provided. Among these are direct labeling of cells with super-paramagnetic agents, radionuclides, and the use of reporter genes for imaging of transplanted cells. In addition, a comprehensive summary is provided of the currently available studies investigating a cell therapy-related effect on left ventricular function, myocardial perfusion, scar tissue, and myocardial viability.
UR - http://www.scopus.com/inward/record.url?scp=33947141093&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947141093&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2006.10.072
DO - 10.1016/j.jacc.2006.10.072
M3 - Review article
C2 - 17367656
AN - SCOPUS:33947141093
SN - 0735-1097
VL - 49
SP - 1137
EP - 1148
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 11
ER -