Abstract
We have previously reported that B10.A (H-2a) mice, which are resistant to the induction of postcoxsackievirus autoimmune myocarditis, become susceptible upon treatment with LPS, IL-1, or TNF. In this study, we show that the development of autoimmune myocarditis is associated with infiltration of the heart by inflammatory cells that secrete the cytokines IL-1 and TNF. Local secretion of these cytokines contributes to increased levels of IL-1 and TNF in the serum. Thus, local production of cytokines promotes the induction of this postinfectious autoimmune disease.
Original language | English (US) |
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Pages (from-to) | 1682-1690 |
Number of pages | 9 |
Journal | Journal of Immunology |
Volume | 151 |
Issue number | 3 |
State | Published - Aug 1 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology