Role of IL-1 and tumor necrosis factor in coxsackie virus-induced autoimmune myocarditis

J. R. Lane, D. A. Neumann, A. Lafond-Walker, A. Herskowitz, N. R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously reported that B10.A (H-2a) mice, which are resistant to the induction of postcoxsackievirus autoimmune myocarditis, become susceptible upon treatment with LPS, IL-1, or TNF. In this study, we show that the development of autoimmune myocarditis is associated with infiltration of the heart by inflammatory cells that secrete the cytokines IL-1 and TNF. Local secretion of these cytokines contributes to increased levels of IL-1 and TNF in the serum. Thus, local production of cytokines promotes the induction of this postinfectious autoimmune disease.

Original languageEnglish (US)
Pages (from-to)1682-1690
Number of pages9
JournalJournal of Immunology
Volume151
Issue number3
StatePublished - 1993

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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