Role of heat shock proteins in atherosclerosis and atrial fibrillation

Sophie Z. Lin, Todd C. Crawford, Kaushik Mandal

Research output: Contribution to journalReview article

Abstract

Heat Shock Proteins (HSPs) are a group of highly conserved molecular chaperones that play important roles in homeostasis and the cellular response to stress. In the cardiovascular system, HSPs maintain vessel wall integrity and cardiomyocyte function; they may be upregulated and translocated to the cell surface in response to environmental stressors. HSPs contribute to the inflammatory processes that mediate the development of atherosclerosis by activating the innate and adaptive immune response. Misdirected autoimmune attack of surface HSPs on stressed vascular endothelial cells by circulating anti-Hsp60 antibodies lead to damage of the vessel wall and atherogenesis. Additionally, other HSPs contribute to the pro-inflammatory state in the vessel wall by stimulating macrophages and reactive T-cells to release cytokine and chemotactic factors. Atrial Fibrillation (AF) is closely related to atherosclerotic burden and changes to levels of various HSPs have been associated with increased incidence of AF in stressed cardiomyocytes after ischemia reperfusion injury. Modulation of HSP expression may be a useful therapeutic strategy in the management of atherosclerosis and AF.

Original languageEnglish (US)
Pages (from-to)71-81
Number of pages11
JournalCurrent Immunology Reviews
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Atherosclerosis
  • Atrial fibrillation
  • Autoimmunity
  • Heat shock proteins
  • HSP
  • HSP60

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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