Role of genetic testing for inherited prostate cancer risk

Philadelphia prostate cancer consensus conference 2017

Veda N. Giri, Karen E. Knudsen, William K. Kelly, Wassim Abida, Gerald L. Andriole, Chris H. Bangma, Justin E. Bekelman, Mitchell C. Benson, Amie Blanco, Arthur Burnett, William J. Catalona, Kathleen A. Cooney, Matthew Cooperberg, David E. Crawford, Robert B. Den, Adam P. Dicker, Scott Eggener, Neil Fleshner, Matthew L. Freedman, Freddie C. Hamdy & 50 others Jean Hoffman-Censits, Mark D. Hurwitz, Colette Hyatt, William B Isaacs, Christopher J. Kane, Philip Kantoff, R. Jeffrey Karnes, Lawrence I. Karsh, Eric A. Klein, Daniel W. Lin, Kevin R. Loughlin, Grace Lu-Yao, S. Bruce Malkowicz, Mark J. Mann, James R. Mark, Peter A. McCue, Martin M. Miner, Todd Morgan, Judd W. Moul, Ronald E. Myers, Sarah M. Nielsen, Elias Obeid, Christian Pavlovich, Stephen C. Peiper, David F. Penson, Daniel Petrylak, Curtis A. Pettaway, Robert Pilarski, Peter A. Pinto, Wendy Poage, Ganesh V. Raj, Timothy R. Rebbeck, Mark E. Robson, Matt T. Rosenberg, Howard Sandler, Oliver Sartor, Edward Schaeffer, Gordon F. Schwartz, Mark S. Shahin, Neal D. Shore, Brian Shuch, Howard R. Soule, Scott A. Tomlins, Edouard J. Trabulsi, Robert Uzzo, Donald J.Vander Griend, Patrick Walsh, Carol J. Weil, Richard Wender, Leonard G. Gomella

Research output: Contribution to journalArticle

Abstract

Purpose: Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods: An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results: Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion: To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA-a clinically heterogeneous disease.

Original languageEnglish (US)
Pages (from-to)414-424
Number of pages11
JournalJournal of Clinical Oncology
Volume36
Issue number4
DOIs
StatePublished - Feb 1 2018

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Genetic Testing
Prostatic Neoplasms
Consensus
Genetic Counseling
Early Detection of Cancer
Hereditary Nonpolyposis Colorectal Neoplasms
DNA Mismatch Repair
Castration
African Americans
Ovarian Neoplasms
Decision Making
Guidelines
Breast Neoplasms
Mutation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Giri, V. N., Knudsen, K. E., Kelly, W. K., Abida, W., Andriole, G. L., Bangma, C. H., ... Gomella, L. G. (2018). Role of genetic testing for inherited prostate cancer risk: Philadelphia prostate cancer consensus conference 2017. Journal of Clinical Oncology, 36(4), 414-424. https://doi.org/10.1200/JCO.2017.74.1173

Role of genetic testing for inherited prostate cancer risk : Philadelphia prostate cancer consensus conference 2017. / Giri, Veda N.; Knudsen, Karen E.; Kelly, William K.; Abida, Wassim; Andriole, Gerald L.; Bangma, Chris H.; Bekelman, Justin E.; Benson, Mitchell C.; Blanco, Amie; Burnett, Arthur; Catalona, William J.; Cooney, Kathleen A.; Cooperberg, Matthew; Crawford, David E.; Den, Robert B.; Dicker, Adam P.; Eggener, Scott; Fleshner, Neil; Freedman, Matthew L.; Hamdy, Freddie C.; Hoffman-Censits, Jean; Hurwitz, Mark D.; Hyatt, Colette; Isaacs, William B; Kane, Christopher J.; Kantoff, Philip; Karnes, R. Jeffrey; Karsh, Lawrence I.; Klein, Eric A.; Lin, Daniel W.; Loughlin, Kevin R.; Lu-Yao, Grace; Malkowicz, S. Bruce; Mann, Mark J.; Mark, James R.; McCue, Peter A.; Miner, Martin M.; Morgan, Todd; Moul, Judd W.; Myers, Ronald E.; Nielsen, Sarah M.; Obeid, Elias; Pavlovich, Christian; Peiper, Stephen C.; Penson, David F.; Petrylak, Daniel; Pettaway, Curtis A.; Pilarski, Robert; Pinto, Peter A.; Poage, Wendy; Raj, Ganesh V.; Rebbeck, Timothy R.; Robson, Mark E.; Rosenberg, Matt T.; Sandler, Howard; Sartor, Oliver; Schaeffer, Edward; Schwartz, Gordon F.; Shahin, Mark S.; Shore, Neal D.; Shuch, Brian; Soule, Howard R.; Tomlins, Scott A.; Trabulsi, Edouard J.; Uzzo, Robert; Griend, Donald J.Vander; Walsh, Patrick; Weil, Carol J.; Wender, Richard; Gomella, Leonard G.

In: Journal of Clinical Oncology, Vol. 36, No. 4, 01.02.2018, p. 414-424.

Research output: Contribution to journalArticle

Giri, VN, Knudsen, KE, Kelly, WK, Abida, W, Andriole, GL, Bangma, CH, Bekelman, JE, Benson, MC, Blanco, A, Burnett, A, Catalona, WJ, Cooney, KA, Cooperberg, M, Crawford, DE, Den, RB, Dicker, AP, Eggener, S, Fleshner, N, Freedman, ML, Hamdy, FC, Hoffman-Censits, J, Hurwitz, MD, Hyatt, C, Isaacs, WB, Kane, CJ, Kantoff, P, Karnes, RJ, Karsh, LI, Klein, EA, Lin, DW, Loughlin, KR, Lu-Yao, G, Malkowicz, SB, Mann, MJ, Mark, JR, McCue, PA, Miner, MM, Morgan, T, Moul, JW, Myers, RE, Nielsen, SM, Obeid, E, Pavlovich, C, Peiper, SC, Penson, DF, Petrylak, D, Pettaway, CA, Pilarski, R, Pinto, PA, Poage, W, Raj, GV, Rebbeck, TR, Robson, ME, Rosenberg, MT, Sandler, H, Sartor, O, Schaeffer, E, Schwartz, GF, Shahin, MS, Shore, ND, Shuch, B, Soule, HR, Tomlins, SA, Trabulsi, EJ, Uzzo, R, Griend, DJV, Walsh, P, Weil, CJ, Wender, R & Gomella, LG 2018, 'Role of genetic testing for inherited prostate cancer risk: Philadelphia prostate cancer consensus conference 2017', Journal of Clinical Oncology, vol. 36, no. 4, pp. 414-424. https://doi.org/10.1200/JCO.2017.74.1173
Giri, Veda N. ; Knudsen, Karen E. ; Kelly, William K. ; Abida, Wassim ; Andriole, Gerald L. ; Bangma, Chris H. ; Bekelman, Justin E. ; Benson, Mitchell C. ; Blanco, Amie ; Burnett, Arthur ; Catalona, William J. ; Cooney, Kathleen A. ; Cooperberg, Matthew ; Crawford, David E. ; Den, Robert B. ; Dicker, Adam P. ; Eggener, Scott ; Fleshner, Neil ; Freedman, Matthew L. ; Hamdy, Freddie C. ; Hoffman-Censits, Jean ; Hurwitz, Mark D. ; Hyatt, Colette ; Isaacs, William B ; Kane, Christopher J. ; Kantoff, Philip ; Karnes, R. Jeffrey ; Karsh, Lawrence I. ; Klein, Eric A. ; Lin, Daniel W. ; Loughlin, Kevin R. ; Lu-Yao, Grace ; Malkowicz, S. Bruce ; Mann, Mark J. ; Mark, James R. ; McCue, Peter A. ; Miner, Martin M. ; Morgan, Todd ; Moul, Judd W. ; Myers, Ronald E. ; Nielsen, Sarah M. ; Obeid, Elias ; Pavlovich, Christian ; Peiper, Stephen C. ; Penson, David F. ; Petrylak, Daniel ; Pettaway, Curtis A. ; Pilarski, Robert ; Pinto, Peter A. ; Poage, Wendy ; Raj, Ganesh V. ; Rebbeck, Timothy R. ; Robson, Mark E. ; Rosenberg, Matt T. ; Sandler, Howard ; Sartor, Oliver ; Schaeffer, Edward ; Schwartz, Gordon F. ; Shahin, Mark S. ; Shore, Neal D. ; Shuch, Brian ; Soule, Howard R. ; Tomlins, Scott A. ; Trabulsi, Edouard J. ; Uzzo, Robert ; Griend, Donald J.Vander ; Walsh, Patrick ; Weil, Carol J. ; Wender, Richard ; Gomella, Leonard G. / Role of genetic testing for inherited prostate cancer risk : Philadelphia prostate cancer consensus conference 2017. In: Journal of Clinical Oncology. 2018 ; Vol. 36, No. 4. pp. 414-424.
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title = "Role of genetic testing for inherited prostate cancer risk: Philadelphia prostate cancer consensus conference 2017",
abstract = "Purpose: Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods: An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results: Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion: To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA-a clinically heterogeneous disease.",
author = "Giri, {Veda N.} and Knudsen, {Karen E.} and Kelly, {William K.} and Wassim Abida and Andriole, {Gerald L.} and Bangma, {Chris H.} and Bekelman, {Justin E.} and Benson, {Mitchell C.} and Amie Blanco and Arthur Burnett and Catalona, {William J.} and Cooney, {Kathleen A.} and Matthew Cooperberg and Crawford, {David E.} and Den, {Robert B.} and Dicker, {Adam P.} and Scott Eggener and Neil Fleshner and Freedman, {Matthew L.} and Hamdy, {Freddie C.} and Jean Hoffman-Censits and Hurwitz, {Mark D.} and Colette Hyatt and Isaacs, {William B} and Kane, {Christopher J.} and Philip Kantoff and Karnes, {R. Jeffrey} and Karsh, {Lawrence I.} and Klein, {Eric A.} and Lin, {Daniel W.} and Loughlin, {Kevin R.} and Grace Lu-Yao and Malkowicz, {S. Bruce} and Mann, {Mark J.} and Mark, {James R.} and McCue, {Peter A.} and Miner, {Martin M.} and Todd Morgan and Moul, {Judd W.} and Myers, {Ronald E.} and Nielsen, {Sarah M.} and Elias Obeid and Christian Pavlovich and Peiper, {Stephen C.} and Penson, {David F.} and Daniel Petrylak and Pettaway, {Curtis A.} and Robert Pilarski and Pinto, {Peter A.} and Wendy Poage and Raj, {Ganesh V.} and Rebbeck, {Timothy R.} and Robson, {Mark E.} and Rosenberg, {Matt T.} and Howard Sandler and Oliver Sartor and Edward Schaeffer and Schwartz, {Gordon F.} and Shahin, {Mark S.} and Shore, {Neal D.} and Brian Shuch and Soule, {Howard R.} and Tomlins, {Scott A.} and Trabulsi, {Edouard J.} and Robert Uzzo and Griend, {Donald J.Vander} and Patrick Walsh and Weil, {Carol J.} and Richard Wender and Gomella, {Leonard G.}",
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TY - JOUR

T1 - Role of genetic testing for inherited prostate cancer risk

T2 - Philadelphia prostate cancer consensus conference 2017

AU - Giri, Veda N.

AU - Knudsen, Karen E.

AU - Kelly, William K.

AU - Abida, Wassim

AU - Andriole, Gerald L.

AU - Bangma, Chris H.

AU - Bekelman, Justin E.

AU - Benson, Mitchell C.

AU - Blanco, Amie

AU - Burnett, Arthur

AU - Catalona, William J.

AU - Cooney, Kathleen A.

AU - Cooperberg, Matthew

AU - Crawford, David E.

AU - Den, Robert B.

AU - Dicker, Adam P.

AU - Eggener, Scott

AU - Fleshner, Neil

AU - Freedman, Matthew L.

AU - Hamdy, Freddie C.

AU - Hoffman-Censits, Jean

AU - Hurwitz, Mark D.

AU - Hyatt, Colette

AU - Isaacs, William B

AU - Kane, Christopher J.

AU - Kantoff, Philip

AU - Karnes, R. Jeffrey

AU - Karsh, Lawrence I.

AU - Klein, Eric A.

AU - Lin, Daniel W.

AU - Loughlin, Kevin R.

AU - Lu-Yao, Grace

AU - Malkowicz, S. Bruce

AU - Mann, Mark J.

AU - Mark, James R.

AU - McCue, Peter A.

AU - Miner, Martin M.

AU - Morgan, Todd

AU - Moul, Judd W.

AU - Myers, Ronald E.

AU - Nielsen, Sarah M.

AU - Obeid, Elias

AU - Pavlovich, Christian

AU - Peiper, Stephen C.

AU - Penson, David F.

AU - Petrylak, Daniel

AU - Pettaway, Curtis A.

AU - Pilarski, Robert

AU - Pinto, Peter A.

AU - Poage, Wendy

AU - Raj, Ganesh V.

AU - Rebbeck, Timothy R.

AU - Robson, Mark E.

AU - Rosenberg, Matt T.

AU - Sandler, Howard

AU - Sartor, Oliver

AU - Schaeffer, Edward

AU - Schwartz, Gordon F.

AU - Shahin, Mark S.

AU - Shore, Neal D.

AU - Shuch, Brian

AU - Soule, Howard R.

AU - Tomlins, Scott A.

AU - Trabulsi, Edouard J.

AU - Uzzo, Robert

AU - Griend, Donald J.Vander

AU - Walsh, Patrick

AU - Weil, Carol J.

AU - Wender, Richard

AU - Gomella, Leonard G.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Purpose: Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods: An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results: Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion: To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA-a clinically heterogeneous disease.

AB - Purpose: Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods: An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results: Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion: To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA-a clinically heterogeneous disease.

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