Role of Environmental Air Pollution in Chronic Rhinosinusitis

Evelyn M. Leland, Zhenyu Zhang, Kathleen M. Kelly, Murugappan Ramanathan

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: Chronic rhinosinusitis (CRS) is a highly prevalent disease with large social and financial burdens. The pathophysiology is multifactorial. Environmental pollutants have been suggested to play a role in the inflammatory component of the disease process. Recent Findings: Recent work has focused on exposure to various pollutants, primarily particulate matter (PM). Exposure to environmental pollutants leads to upregulation of inflammatory markers and ciliary dysfunction at the cellular level. Mouse models suggest a role for epithelial barrier dysfunction contributing to inflammatory changes after pollutant exposure. Clinical studies support the role of pollutants contributing to disease severity in certain populations, but the role in CRS incidence or prevalence is less clear. Research is limited by the retrospective nature of most studies. Summary: This review focuses on recent advancements in our understanding of the impact of environmental pollutants in CRS, limitations of the available data, and potential opportunities for future studies.

Original languageEnglish (US)
Article number42
JournalCurrent allergy and asthma reports
Issue number8
StatePublished - Aug 2021


  • Air pollution
  • Chronic rhinosinusitis
  • Environmental exposure
  • Environmental pollutants
  • Pollution

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Role of Environmental Air Pollution in Chronic Rhinosinusitis'. Together they form a unique fingerprint.

Cite this