TY - JOUR
T1 - Role of endothelin in the exercise intolerance of chronic heart failure
AU - Krum, Henry
AU - Goldsmith, Rochelle
AU - Wilshire-Clement, Michelle
AU - Miller, Myron
AU - Packer, Milton
PY - 1995/6/15
Y1 - 1995/6/15
N2 - In conclusion, plasma levels of the endothelialderived vasoconstrictor endothelin-1 (but not those of other neurohormonal vasoconstrictor factors), measured during exercise correlated closely with objective variables of exercise capacity in patients with heart failure. These findings suggest that endothelin-1 may contribute to exercise intolerance in patients with heart failure, perhaps by limiting the ability of the peripheral vasculature to dilate during exercise.
AB - In conclusion, plasma levels of the endothelialderived vasoconstrictor endothelin-1 (but not those of other neurohormonal vasoconstrictor factors), measured during exercise correlated closely with objective variables of exercise capacity in patients with heart failure. These findings suggest that endothelin-1 may contribute to exercise intolerance in patients with heart failure, perhaps by limiting the ability of the peripheral vasculature to dilate during exercise.
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U2 - 10.1016/S0002-9149(99)80783-8
DO - 10.1016/S0002-9149(99)80783-8
M3 - Article
C2 - 7778560
AN - SCOPUS:58149209135
SN - 0002-9149
VL - 75
SP - 1282
EP - 1283
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 17
ER -