Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy

Li Ping Yang, Le Meng Wu, Dong Mei Wang, Ying Li, Hong Liang Dou, Mark O.M. Tso, Zhi Zhong Ma

Research output: Contribution to journalArticle

Abstract

Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. In the present study, a streptozotocin-induced diabetic animal model was given an intraperitoneal injection of tauroursodeoxycholic acid. Results from immunofluorescent co-localization experiments showed that both caspase-12 protein and c-Jun N-terminal kinase 1 phosphorylation levels significantly increased, which was associated with retinal ganglion cell death in diabetic retinas. The C/ERB mologous protein pathway directly contributed to glial reactivity, and was subsequently responsible for neuronal loss and vascular abnormalities in diabetic retinopathy. Our experimental findings dicate that endoplasmic reticulum stress plays an important role in diabetes-induced retinal neuronal loss and vascular abnormalities, and that inhibiting the activation of the endoplasmic reticulum stress pathway provides effective protection against diabetic retinopathy.

Original languageEnglish (US)
Pages (from-to)3148-3158
Number of pages11
JournalNeural Regeneration Research
Volume8
Issue number33
DOIs
StatePublished - Nov 25 2013

Keywords

  • Astrocytes
  • C-Jun N-terminal kinase
  • C/ERB homologous protein
  • Caspase-12 protein
  • Diabetic retinopathy
  • Endoplasmic reticulum stress
  • Glial fibrillary acidic protein
  • Grant-supported paper
  • Injury of retinal ganglion cells
  • Müller cells
  • Neural regeneration
  • Neuroregeneration
  • Peripheral nerve injury
  • Retinal microcirculation

ASJC Scopus subject areas

  • Developmental Neuroscience

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