Role of endogenous testosterone concentration in pediatric stroke

Sandra Normann, Gabrielle De Veber, Manfred Fobker, Claus Langer, Gili Kenet, Timothy J. Bernard, Barbara Fiedler, Ronald Sträter, Neil A. Goldenberg, Ulrike Nowak-Göttl

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured in children with arterial ischemic stroke (AIS; n = 72), children with cerebral sinovenous thrombosis (CSVT; n = 52), and 109 healthy controls. Testosterone levels above the 90th percentile for age and gender were documented in 10 children with AIS (13.9%) and 10 with CSVT (19.2%), totaling 16.7% of patients with cerebral thromboembolism overall, as compared with only 2 of 109 controls (1.8%; p = 0.002). In multivariate analysis with adjustment for total cholesterol level, hematocrit, and pubertal status, elevated testosterone was independently associated with increased disease risk (odds ratio [95% confidence interval]: overall = 3.98 [1.38-11.45]; AIS = 3.88 [1.13-13.35]; CSVT = 5.50 [1.65-18.32]). Further adjusted analyses revealed that, for each 1nmol/l increase in testosterone in boys, the odds of cerebral thromboembolism were increased 1.3-fold.

Original languageEnglish (US)
Pages (from-to)754-758
Number of pages5
JournalAnnals of neurology
Volume66
Issue number6
DOIs
StatePublished - Dec 2009
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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