Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study

Javier Saiz, Marta Monserrat, Jose M. Ferrero, Jose M. Ferrero, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have used a computer model of the ventricular action potential to study conditions in which EADs developed in an area of ventricular myocardium can propagate to other areas, generating ectopic activity. We simulate the interactions between two areas of myocardium; one of them can develop EADs while the other is kept under normal conditions. Both zones are coupled through an area of inexcitable tissue, simulated by a resistance R. The results show that for values of R in the range from 38Ωcm2 to 50 Ωcm2, the EAD generated in the abnormal zone is propagated to the normal area as an ectopic beat. For R values out of this range, when the action potential propagates, the EAD only induces lengthening of action potential in some cells of the normal zone and ectopic activity on normal cells is not observed.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages1842-1843
Number of pages2
Volume5
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth
Duration: Oct 31 1996Nov 3 1996

Other

OtherProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5)
CityAmsterdam, Neth
Period10/31/9611/3/96

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Computer simulation

ASJC Scopus subject areas

  • Bioengineering

Cite this

Saiz, J., Monserrat, M., Ferrero, J. M., Ferrero, J. M., & Thakor, N. V. (1996). Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 5, pp. 1842-1843). IEEE.

Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study. / Saiz, Javier; Monserrat, Marta; Ferrero, Jose M.; Ferrero, Jose M.; Thakor, Nitish V.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 5 IEEE, 1996. p. 1842-1843.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Saiz, J, Monserrat, M, Ferrero, JM, Ferrero, JM & Thakor, NV 1996, Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 5, IEEE, pp. 1842-1843, Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5), Amsterdam, Neth, 10/31/96.
Saiz J, Monserrat M, Ferrero JM, Ferrero JM, Thakor NV. Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 5. IEEE. 1996. p. 1842-1843
Saiz, Javier ; Monserrat, Marta ; Ferrero, Jose M. ; Ferrero, Jose M. ; Thakor, Nitish V. / Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 5 IEEE, 1996. pp. 1842-1843
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abstract = "We have used a computer model of the ventricular action potential to study conditions in which EADs developed in an area of ventricular myocardium can propagate to other areas, generating ectopic activity. We simulate the interactions between two areas of myocardium; one of them can develop EADs while the other is kept under normal conditions. Both zones are coupled through an area of inexcitable tissue, simulated by a resistance R. The results show that for values of R in the range from 38Ωcm2 to 50 Ωcm2, the EAD generated in the abnormal zone is propagated to the normal area as an ectopic beat. For R values out of this range, when the action potential propagates, the EAD only induces lengthening of action potential in some cells of the normal zone and ectopic activity on normal cells is not observed.",
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