Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study

Javier Saiz, Marta Monserrat, Jose M. Ferrero, Jose M. Ferrero, Nitish V. Thakor

Research output: Contribution to journalConference article

Abstract

We have used a computer model of the ventricular action potential to study conditions in which EADs developed in an area of ventricular myocardium can propagate to other areas, generating ectopic activity. We simulate the interactions between two areas of myocardium; one of them can develop EADs while the other is kept under normal conditions. Both zones are coupled through an area of inexcitable tissue, simulated by a resistance R. The results show that for values of R in the range from 38Ωcm2 to 50 Ωcm2, the EAD generated in the abnormal zone is propagated to the normal area as an ectopic beat. For R values out of this range, when the action potential propagates, the EAD only induces lengthening of action potential in some cells of the normal zone and ectopic activity on normal cells is not observed.

Original languageEnglish (US)
Pages (from-to)1842-1843
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume5
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth
Duration: Oct 31 1996Nov 3 1996

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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