Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study

Javier Saiz; Marta Monserrat; Jose M. Ferrero; Jose M. Ferrero; Nitish V. Thakor

Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study

Javier Saiz, Marta Monserrat, Jose M. Ferrero, Jose M. Ferrero, Nitish V. Thakor

Research output: Contribution to journal › Conference article › peer-review

Abstract

We have used a computer model of the ventricular action potential to study conditions in which EADs developed in an area of ventricular myocardium can propagate to other areas, generating ectopic activity. We simulate the interactions between two areas of myocardium; one of them can develop EADs while the other is kept under normal conditions. Both zones are coupled through an area of inexcitable tissue, simulated by a resistance R. The results show that for values of R in the range from 38Ωcm² to 50 Ωcm², the EAD generated in the abnormal zone is propagated to the normal area as an ectopic beat. For R values out of this range, when the action potential propagates, the EAD only induces lengthening of action potential in some cells of the normal zone and ectopic activity on normal cells is not observed.

Original language	English (US)
Pages (from-to)	1842-1843
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	5
State	Published - 1996
Externally published	Yes
Event	Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth Duration: Oct 31 1996 → Nov 3 1996

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Cite this

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title = "Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study",

abstract = "We have used a computer model of the ventricular action potential to study conditions in which EADs developed in an area of ventricular myocardium can propagate to other areas, generating ectopic activity. We simulate the interactions between two areas of myocardium; one of them can develop EADs while the other is kept under normal conditions. Both zones are coupled through an area of inexcitable tissue, simulated by a resistance R. The results show that for values of R in the range from 38Ωcm2 to 50 Ωcm2, the EAD generated in the abnormal zone is propagated to the normal area as an ectopic beat. For R values out of this range, when the action potential propagates, the EAD only induces lengthening of action potential in some cells of the normal zone and ectopic activity on normal cells is not observed.",

author = "Javier Saiz and Marta Monserrat and Ferrero, {Jose M.} and Ferrero, {Jose M.} and Thakor, {Nitish V.}",

year = "1996",

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pages = "1842--1843",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) ; Conference date: 31-10-1996 Through 03-11-1996",

}

TY - JOUR

T1 - Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study

AU - Saiz, Javier

AU - Monserrat, Marta

AU - Ferrero, Jose M.

AU - Thakor, Nitish V.

PY - 1996

Y1 - 1996

N2 - We have used a computer model of the ventricular action potential to study conditions in which EADs developed in an area of ventricular myocardium can propagate to other areas, generating ectopic activity. We simulate the interactions between two areas of myocardium; one of them can develop EADs while the other is kept under normal conditions. Both zones are coupled through an area of inexcitable tissue, simulated by a resistance R. The results show that for values of R in the range from 38Ωcm2 to 50 Ωcm2, the EAD generated in the abnormal zone is propagated to the normal area as an ectopic beat. For R values out of this range, when the action potential propagates, the EAD only induces lengthening of action potential in some cells of the normal zone and ectopic activity on normal cells is not observed.

AB - We have used a computer model of the ventricular action potential to study conditions in which EADs developed in an area of ventricular myocardium can propagate to other areas, generating ectopic activity. We simulate the interactions between two areas of myocardium; one of them can develop EADs while the other is kept under normal conditions. Both zones are coupled through an area of inexcitable tissue, simulated by a resistance R. The results show that for values of R in the range from 38Ωcm2 to 50 Ωcm2, the EAD generated in the abnormal zone is propagated to the normal area as an ectopic beat. For R values out of this range, when the action potential propagates, the EAD only induces lengthening of action potential in some cells of the normal zone and ectopic activity on normal cells is not observed.

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M3 - Conference article

AN - SCOPUS:0030315630

SN - 0589-1019

VL - 5

SP - 1842

EP - 1843

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

T2 - Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5)

Y2 - 31 October 1996 through 3 November 1996

ER -

Role of early afterdepolarizations on ectopic activity in ventricular tissue. A computer modeling study

Abstract

ASJC Scopus subject areas

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