Role of diffusion-weighted imaging in differentiating benign and malignant pediatric abdominal tumors

Rakhee Gawande, Gabriel Gonzalez, Solomon Messing, Aman Khurana, Heike E. Daldrup-Link

Research output: Contribution to journalArticle

Abstract

Background: Solid malignant tumors are more highly cellular than benign lesions and hence have a restricted diffusion of water molecules. Objective: To evaluate whether diffusion-weighted MR imaging (DWI) can differentiate between benign and malignant pediatric abdominal tumors. Materials and methods: We retrospectively analyzed DWI scans of 68 consecutive children with 39 benign and 34 malignant abdominal masses. To calculate the apparent diffusion coefficient (ADC) maps and ADC values, we used 1.5-T sequences at TR/TE/b-value of 5,250-7,500/54-64/b = 0, 500 and 3-T sequences at 3,500-4,000/66-73/b = 0, 500, 800. ADC values were compared between benign and malignant and between data derived at 1.5 tesla (T) and at 3 tesla magnetic field strength, using the Mann-Whitney-Wilcoxon test, ANOVA and a receiver operating curve (ROC) analysis. Results: There was no significant difference in ADC values obtained at 1.5 T and 3 T (P = 0.962). Mean ADC values (× 10-3 mm2/s) were 1.07 for solid malignant tumors, 1.6 for solid benign tumors, 2.9 for necrotic portions of malignant tumors and 3.1 for cystic benign lesions. The differences between malignant and benign solid tumors were statistically significant (P = 0.000025). ROC analysis revealed an optimal cut-off ADC value for differentiating malignant and benign solid tumors as 1.29 with excellent inter-observer reliability (alpha score 0.88). Conclusion: DWI scans and ADC values can contribute to distinguishing between benign and malignant pediatric abdominal tumors.

Original languageEnglish (US)
Pages (from-to)836-845
Number of pages10
JournalPediatric Radiology
Volume43
Issue number7
DOIs
StatePublished - Jul 1 2013
Externally publishedYes

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Pediatrics
Neoplasms
Magnetic Fields
Analysis of Variance
Water

Keywords

  • Benign
  • Children
  • Diffusion-weighted imaging
  • Malignant
  • MRI
  • Pediatric abdominal neoplasm

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pediatrics, Perinatology, and Child Health

Cite this

Role of diffusion-weighted imaging in differentiating benign and malignant pediatric abdominal tumors. / Gawande, Rakhee; Gonzalez, Gabriel; Messing, Solomon; Khurana, Aman; Daldrup-Link, Heike E.

In: Pediatric Radiology, Vol. 43, No. 7, 01.07.2013, p. 836-845.

Research output: Contribution to journalArticle

Gawande, Rakhee ; Gonzalez, Gabriel ; Messing, Solomon ; Khurana, Aman ; Daldrup-Link, Heike E. / Role of diffusion-weighted imaging in differentiating benign and malignant pediatric abdominal tumors. In: Pediatric Radiology. 2013 ; Vol. 43, No. 7. pp. 836-845.
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