Role of CR4 in Mycobacterium tuberculosis-human macrophages binding and signal transduction in the absence of serum

Y. Zaffran, L. Zhang, J. J. Ellner

Research output: Contribution to journalArticlepeer-review

Abstract

The β2 integrin CR4 is involved in Mycobacterium tuberculosis phagocytosis by human mononuclear phagocytes through the opsonin C3bi. In this study, we demonstrate that M. tuberculosis can bind directly to monocyte-derived macrophages via CR4 in the absence of any opsonins. CR4- transfected CHO cells gave similar results, suggesting recognition by CR4 of bacterial structure. Furthermore, binding of M. tuberculosis transduced a potent signal, resulting in tyrosine phosphorylation of macrophage proteins, which was in part mediated by CR4.

Original languageEnglish (US)
Pages (from-to)4541-4544
Number of pages4
JournalInfection and Immunity
Volume66
Issue number9
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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