Role of complement in viral infections: Participation of terminal complement components (C5 to C9) in recovery of mice from Sindbis virus infection

R. L. Hirsch, D. E. Griffin, J. A. Winkelstein

Research output: Contribution to journalArticle

Abstract

The pathogenesis of Sindbis virus infection was studied in congenic mice with normal levels of the fifth component of complement (C5) and in mice deficient in C5. Mice deficient in C5 had a higher mortality rate than mice with normal levels of C5 as well as impaired clearance of virus from their brains and feet.

Original languageEnglish (US)
Pages (from-to)899-901
Number of pages3
JournalInfection and immunity
Volume30
Issue number3
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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