Role of Ca2+ sparks in the regulation of pulmonary vascular tone

James Sham, Anita Umesh, Xiao Ru Yang, Mo Jun Lin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In biological systems, intracellular Ca2+ ions serve as a ubiquitous messenger for numerous cellular functions ranging from muscle contraction to gene expression. Ca2+ signals are generated by multiple specific Ca2+ transporters, delivered globally or locally, and decoded by various effectors according to the signal amplitude and frequency in their immediate vicinities (1). In pulmonary vascular smooth muscle, major attention has been focused on the global elevation of [Ca2+]i, because it is responsible for the initiation of actin-myosin interactions during smooth muscle contraction. However, due to the spatial distribution of different Ca2+ transporters, the diffusion kinetics of Ca2+ ions, and the subcellular microarchitecture, heterogeneity in local [Ca2+] is expected. It has been estimated on theoretical grounds that [Ca2+] can exceed 100 mM in the vicinity (Ca2+ microdomain) of an open Ca2+ conducting channel (2). Such large local gradients of [Ca2+] can provide fast and specific Ca2+ signals to neighboring effector molecules to trigger Ca2+-dependent processes that may not be responsive to global submicromolar increase in [Ca2+]i.

Original languageEnglish (US)
Title of host publicationIon Channels in the Pulmonary Vasculature
PublisherCRC Press
Pages483-512
Number of pages30
ISBN (Electronic)9780849350375
ISBN (Print)0824759680, 9780824759681
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Sham, J., Umesh, A., Yang, X. R., & Lin, M. J. (2005). Role of Ca2+ sparks in the regulation of pulmonary vascular tone. In Ion Channels in the Pulmonary Vasculature (pp. 483-512). CRC Press.