Role of Ca2+ in toxic cell killing

Sten Orrenius, David J. McConkey, Giorgio Bellomo, Pierluigi Nicotera

Research output: Contribution to journalReview articlepeer-review


Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.

Original languageEnglish (US)
Pages (from-to)281-285
Number of pages5
JournalTrends in Pharmacological Sciences
Issue number7
StatePublished - Jul 1989
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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