Role of Ca2+ in toxic cell killing

Sten Orrenius; David J. McConkey; Giorgio Bellomo; Pierluigi Nicotera

doi:10.1016/0165-6147(89)90029-1

Role of Ca²⁺ in toxic cell killing

Sten Orrenius, David J. McConkey, Giorgio Bellomo, Pierluigi Nicotera

Research output: Contribution to journal › Review article › peer-review

773 Scopus citations

Abstract

Recent work has shown that a sustained increase in cytosolic Ca²⁺ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca²⁺ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.

Original language	English (US)
Pages (from-to)	281-285
Number of pages	5
Journal	Trends in Pharmacological Sciences
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/0165-6147(89)90029-1
State	Published - Jul 1989
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/0165-6147(89)90029-1

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title = "Role of Ca2+ in toxic cell killing",

abstract = "Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.",

author = "Sten Orrenius and McConkey, {David J.} and Giorgio Bellomo and Pierluigi Nicotera",

year = "1989",

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AU - Orrenius, Sten

AU - McConkey, David J.

AU - Bellomo, Giorgio

AU - Nicotera, Pierluigi

PY - 1989/7

Y1 - 1989/7

N2 - Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.

AB - Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.

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DO - 10.1016/0165-6147(89)90029-1

M3 - Review article

C2 - 2672472

AN - SCOPUS:0024473819

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JO - Trends in Pharmacological Sciences

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Role of Ca²⁺ in toxic cell killing

Abstract

ASJC Scopus subject areas

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