Role of Ca2+ in toxic cell killing

Sten Orrenius, David J. McConkey, Giorgio Bellomo, Pierluigi Nicotera

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.

Original languageEnglish (US)
Pages (from-to)281-285
Number of pages5
JournalTrends in Pharmacological Sciences
Volume10
Issue number7
DOIs
StatePublished - Jul 1989
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Fingerprint

Dive into the research topics of 'Role of Ca2+ in toxic cell killing'. Together they form a unique fingerprint.

Cite this