Role of Btk in B cell development and signaling

Research output: Contribution to journalArticlepeer-review


Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.

Original languageEnglish (US)
Pages (from-to)534-540
Number of pages7
JournalCurrent Opinion in Immunology
Issue number4
StatePublished - Aug 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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