Role of Btk in B cell development and signaling

Stephen Desiderio

doi:10.1016/S0952-7915(97)80107-0

Role of Btk in B cell development and signaling

Stephen Desiderio

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.

Original language	English (US)
Pages (from-to)	534-540
Number of pages	7
Journal	Current Opinion in Immunology
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/S0952-7915(97)80107-0
State	Published - Aug 1997
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0952-7915(97)80107-0

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title = "Role of Btk in B cell development and signaling",

abstract = "Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.",

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AB - Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.

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Role of Btk in B cell development and signaling

Abstract

ASJC Scopus subject areas

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