Role of Btk in B cell development and signaling

Research output: Contribution to journalArticle

Abstract

Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.

Original languageEnglish (US)
Pages (from-to)534-540
Number of pages7
JournalCurrent Opinion in Immunology
Volume9
Issue number4
DOIs
StatePublished - Aug 1997
Externally publishedYes

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B-Lymphocytes
X-Linked Combined Immunodeficiency Diseases
Mutation
Agammaglobulinaemia tyrosine kinase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Role of Btk in B cell development and signaling. / Desiderio, Stephen.

In: Current Opinion in Immunology, Vol. 9, No. 4, 08.1997, p. 534-540.

Research output: Contribution to journalArticle

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