Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens

Alex Y.C. Huang, Paul Golumbek, Mojgan Ahmadzadeh, Elizabeth Jaffee, Drew Pardoll, Hyam Levitsky

Research output: Contribution to journalArticlepeer-review

Abstract

Many tumors express tumor-specific antigens capable of being presented to CD8+ T cells by major histocompatibility complex (MHC) class 1 molecules. Antigen presentation models predict that the tumor cell itself should present these antigens to T cells. However, when conditions for the priming of tumor-specific responses were examined in mice, no detectable presentation of MHC class 1-restricted tumor antigens by the tumor itself was found. Rather, tumor antigens were exclusively presented by host bone marrow-derived cells. Thus, MHC class 1-restricted antigens are efficiently transferred in vivo to bone marrow-derived antigen-presenting cells, which suggests that human leukocyte antigen matching may be less critical in the application of tumor vaccines than previously thought.

Original languageEnglish (US)
Pages (from-to)961-965
Number of pages5
JournalScience
Volume264
Issue number5161
DOIs
StatePublished - May 13 1994

ASJC Scopus subject areas

  • General

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