Role of arginine vasopressin receptor antagonists in hyponatremia in the elderly

Research output: Contribution to journalArticle

Abstract

Hyponatremia can occur at any age, but it is especially prevalent among the elderly, particularly those in acute care hospitals and long-term care facilities. The increased incidence in these patient groups is attributable to age-related impairment of fluid and electrolyte balance, use of multiple drugs that can precipitate hyponatremia, and increased vulnerability to diseases associated with hyponatremia. Recent evidence suggests that even mild chronic hyponatremia can have serious consequences in the elderly. Many current treatments for hyponatremia are limited by poor compliance, inconsistent or delayed response, or risk of adverse effects. Arginine vasopressin (AVP) receptor antagonists, a new class of drugs that block the binding of AVP to V 2 receptors in the kidney's collecting tubules, may provide a safe and effective alternative.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalGeriatrics
Volume62
Issue number7
StatePublished - Jul 2007

Fingerprint

Vasopressin Receptors
Hyponatremia
Water-Electrolyte Balance
Collecting Kidney Tubules
Arginine Vasopressin
Long-Term Care
Pharmaceutical Preparations
Antidiuretic Hormone Receptor Antagonists
Incidence

Keywords

  • Aquaretics
  • Arginine vasopressin (AVP)
  • Hyponatremia
  • SIADH

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Role of arginine vasopressin receptor antagonists in hyponatremia in the elderly. / Miller, Myron.

In: Geriatrics, Vol. 62, No. 7, 07.2007, p. 20-26.

Research output: Contribution to journalArticle

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