Role of antiheat shock protein 60 autoantibodies in atherosclerosis

Kaushik Mandal, G. Foteinos, M. Jahangiri, Qingbo Xu

Research output: Contribution to journalArticle

Abstract

Immuno-inflammatory processes are implicated, as one of the prime pathogenic processes involved, in the development and progression of early atherosclerosis. High levels of circulating antiheat shock protein 60 (HSP60) autoantibodies have been associated with increasing severity of atherosclerosis in patients. We have recently presented evidence, extending this statistical association to that of causality, by showing that anti-HSP60 antibodies purified from sera of patients with documented atherosclerosis when injected into tail vein of apoE deficient mice resulted in accelerated atherosclerosis in them. High degree of sequence homology between microbial and mammalian HSP60, due to evolutionary conservation, carries a risk of misdirected autoimmunity against HSPs expressed on the stressed cells of vascular endothelium. HSPs and anti-HSP antibodies have been shown to elicit production of pro-inflammatory cytokines. These autoimmune reactions to HSPs expressed in the vascular tissue can contribute to both initiation and perpetuation of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)742-746
Number of pages5
JournalLupus
Volume14
Issue number9
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Autoantibodies
Shock
Atherosclerosis
Proteins
Anti-Idiotypic Antibodies
Vascular Endothelium
Apolipoproteins E
Sequence Homology
Autoimmunity
Causality
Blood Vessels
Tail
Veins
Cytokines
Serum

Keywords

  • Atherosclerosis
  • Autoimmunity
  • Heat shock protein (HSP)

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Mandal, K., Foteinos, G., Jahangiri, M., & Xu, Q. (2005). Role of antiheat shock protein 60 autoantibodies in atherosclerosis. Lupus, 14(9), 742-746. https://doi.org/10.1191/0961203305lu2212oa

Role of antiheat shock protein 60 autoantibodies in atherosclerosis. / Mandal, Kaushik; Foteinos, G.; Jahangiri, M.; Xu, Qingbo.

In: Lupus, Vol. 14, No. 9, 2005, p. 742-746.

Research output: Contribution to journalArticle

Mandal, K, Foteinos, G, Jahangiri, M & Xu, Q 2005, 'Role of antiheat shock protein 60 autoantibodies in atherosclerosis', Lupus, vol. 14, no. 9, pp. 742-746. https://doi.org/10.1191/0961203305lu2212oa
Mandal, Kaushik ; Foteinos, G. ; Jahangiri, M. ; Xu, Qingbo. / Role of antiheat shock protein 60 autoantibodies in atherosclerosis. In: Lupus. 2005 ; Vol. 14, No. 9. pp. 742-746.
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