Abstract
Amide proton transfer (APT) imaging is a novel molecular MRI technique that can provide endogenous contrast related to mobile protein content in tissue. The preclinical studies and pilot clinical data have shown initial potential for APT imaging to assess brain tumors, such as differentiating between tumor and peritumoral edema, separating high- from low-grade gliomas, and distinguishing between active tumor and radiation necrosis. In this chapter, we briefly introduce the basic principle of APT imaging and overview its current applications for brain tumor assessment in animal models and in patients.
Original language | English (US) |
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Title of host publication | Functional Brain Tumor Imaging |
Publisher | Springer New York |
Pages | 171-181 |
Number of pages | 11 |
Volume | 9781441958587 |
ISBN (Electronic) | 9781441958587 |
ISBN (Print) | 1441958576, 9781441958570 |
DOIs | |
State | Published - May 1 2013 |
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology