Role of amide proton transfer (APT)-MRI of endogenous proteins and peptides in brain tumor imaging

Silun Wang, Samson Jarso, Peter C.M. Van Zijl, Jinyuan Zhou

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Amide proton transfer (APT) imaging is a novel molecular MRI technique that can provide endogenous contrast related to mobile protein content in tissue. The preclinical studies and pilot clinical data have shown initial potential for APT imaging to assess brain tumors, such as differentiating between tumor and peritumoral edema, separating high- from low-grade gliomas, and distinguishing between active tumor and radiation necrosis. In this chapter, we briefly introduce the basic principle of APT imaging and overview its current applications for brain tumor assessment in animal models and in patients.

Original languageEnglish (US)
Title of host publicationFunctional Brain Tumor Imaging
PublisherSpringer New York
Pages171-181
Number of pages11
Volume9781441958587
ISBN (Electronic)9781441958587
ISBN (Print)1441958576, 9781441958570
DOIs
StatePublished - May 1 2013

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ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wang, S., Jarso, S., Van Zijl, P. C. M., & Zhou, J. (2013). Role of amide proton transfer (APT)-MRI of endogenous proteins and peptides in brain tumor imaging. In Functional Brain Tumor Imaging (Vol. 9781441958587, pp. 171-181). Springer New York. https://doi.org/10.1007/978-1-4419-5858-7_10