Role of Alzheimer's disease models in designing and testing experimental therapeutics

Alena V. Savonenko, Fiona M. Laird, Juan C. Troncoso, Philip C. Wong, Donald L. Price

Research output: Contribution to journalReview articlepeer-review

Abstract

The principal goals of investigating the models for Alzheimer's disease (AD) are to reproduce the amyloid/tau-related pathologies and the memory deficits occurring in patients. Recent models do allow crucial examinations of disease mechanisms and will be of great value in testing new therapeutic strategies including inhibition of BACE1 and β-secretase activities, modulators of γ-secretase and Aβ immunotherapies. Presently available mouse models can achieve a high degree of predictive validity for positive outcomes of experimental therapies, but they have been less successful in identifying potential adverse outcomes that can occur in human trials.

Original languageEnglish (US)
Pages (from-to)305-312
Number of pages8
JournalDrug Discovery Today: Disease Models
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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