TY - JOUR
T1 - Role of adipokines and inflammatory markers in postmenopausal hypertension
AU - July, Mose
AU - Faiz, Saba
AU - Yaqub, Abid
AU - Santhanam, Prasanna
AU - Douglas, Jillian
AU - Stanek, Ronald
AU - Gress, Todd
AU - Olajide, Omolola
AU - Driscoll, Henry
AU - Santanam, Nalini
PY - 2018/6/1
Y1 - 2018/6/1
N2 - BACKGROUND: The role of inflammatory markers and adipokines contributing to the development of postmenopausal hypertension, has not been established. The aim of our study was to assess the complex association between blood pressure, obesity, menopausal status, adipokines and inflammatory mediators in postmenopausal women. METHODS: We recruited 38 women seen at our Endocrinology Clinic and collected anthropometric measures and blood pressure and obtained serum samples for inflammatory markers and adipokine levels. Out of 38 women, 23 (60%) were postmenopausal. RESULTS: In the pre-menopausal and postmenopausal women, there were no significant differences in measured adipokines and inflammatory markers based on hypertensive status. When obesity was eliminated, significantly higher levels of EGF, IL-8, MCP1 and TNF-α and lower levels of IL-1α and IL-3 were observed in the postmenopausal group (P<0.05). Women with higher waist-to-hip ratio (WHR) had a significant trend towards lower adiponectin levels as compared to those with lower WHR (P=0.014 and P=0.04, respectively). CONCLUSIONS: There was a significant difference in pro-inflammatory markers in non-obese, pre- And post-menopausal women. These higher inflammatory markers might play a role in the development of post-menopausal hypertension.
AB - BACKGROUND: The role of inflammatory markers and adipokines contributing to the development of postmenopausal hypertension, has not been established. The aim of our study was to assess the complex association between blood pressure, obesity, menopausal status, adipokines and inflammatory mediators in postmenopausal women. METHODS: We recruited 38 women seen at our Endocrinology Clinic and collected anthropometric measures and blood pressure and obtained serum samples for inflammatory markers and adipokine levels. Out of 38 women, 23 (60%) were postmenopausal. RESULTS: In the pre-menopausal and postmenopausal women, there were no significant differences in measured adipokines and inflammatory markers based on hypertensive status. When obesity was eliminated, significantly higher levels of EGF, IL-8, MCP1 and TNF-α and lower levels of IL-1α and IL-3 were observed in the postmenopausal group (P<0.05). Women with higher waist-to-hip ratio (WHR) had a significant trend towards lower adiponectin levels as compared to those with lower WHR (P=0.014 and P=0.04, respectively). CONCLUSIONS: There was a significant difference in pro-inflammatory markers in non-obese, pre- And post-menopausal women. These higher inflammatory markers might play a role in the development of post-menopausal hypertension.
KW - Key words: Adiponectin - biomarkers - inflammation - obesity - waist-hip ratio
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U2 - 10.23736/S0391-1977.17.02595-0
DO - 10.23736/S0391-1977.17.02595-0
M3 - Article
C2 - 28565888
AN - SCOPUS:85030664387
SN - 0391-1977
VL - 43
SP - 101
EP - 108
JO - Minerva Endocrinologica
JF - Minerva Endocrinologica
IS - 2
ER -