Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation

Douglas E. Vetter, M. Charles Liberman, Jeffrey Mann, Jacques Barhanin, Jim Boulter, M. Christian Brown, Joanne Saffiote-Kolman, Stephen F. Heinemann, A. Belén Elgoyhen

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Abstract

Cochlear outer hair cells (OHCs) express α9 nACh receptors and are contacted by descending, predominately cholinergic, efferent fibers originating in the CNS. Mice carrying a null mutation for the nACh α9 gene were produced to investigate its role(s) in auditory processing and development of hair cell innervation. In α9 knockout mice, most OHCs were innervated by one large terminal instead of multiple smaller terminals as in wild types, suggesting a role for the nACh α9 subunit in development of mature synaptic connections. α9 knockout mice also failed to show suppression of cochlear responses (compound action potentials, distortion product otoacoustic emissions) during efferent fiber activation, demonstrating the key role α9 receptors play in mediating the only known effects of the olivocochlear system.

Original languageEnglish (US)
Pages (from-to)93-103
Number of pages11
JournalNeuron
Volume23
Issue number1
DOIs
StatePublished - May 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vetter, D. E., Liberman, M. C., Mann, J., Barhanin, J., Boulter, J., Brown, M. C., Saffiote-Kolman, J., Heinemann, S. F., & Elgoyhen, A. B. (1999). Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron, 23(1), 93-103. https://doi.org/10.1016/S0896-6273(00)80756-4