Abstract
Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of fragile X and related disorders.
Original language | English (US) |
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Pages (from-to) | 1503-1508 |
Number of pages | 6 |
Journal | Journal of Physiology |
Volume | 586 |
Issue number | 6 |
DOIs | |
State | Published - Mar 15 2008 |
ASJC Scopus subject areas
- Physiology