Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome

Gül Dölen, Mark F. Bear

Research output: Contribution to journalArticlepeer-review

Abstract

Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of fragile X and related disorders.

Original languageEnglish (US)
Pages (from-to)1503-1508
Number of pages6
JournalJournal of Physiology
Volume586
Issue number6
DOIs
StatePublished - Mar 15 2008

ASJC Scopus subject areas

  • Physiology

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