Role and regulation of urea transporters

Research output: Contribution to journalArticle

Abstract

In the past few years, significant knowledge has been gained about the physiological role and regulation of urea transporters, which have been now cloned in many species. The two major mammalian urea transporters, UT-A and UT-B, have been best studied in the kidney, where they mediate the facilitated diffusion of urea across tubular, interstitial, and vascular compartments, necessary to maintain an osmolar gradient along the renal corticomedullary axis. The genes encoding these transporters, Slc14A2 for UT-A and Slc14A1 for UT-B, have been characterized in rodents and humans, allowing identification of transcriptional mechanisms involved in the regulation of UT-A expression. The crucial role that urea transporters play in renal physiology is underscored by the phenotypic characteristics of UT-A and UT-B knockout mice, in which lack of specific urea transporters impairs the ability to concentrate urine. Expression of the UT-A and UT-B transporters has also been identified in extra-renal sites, where their physiological significance is only beginning to be elucidated. More information on the mechanisms modulating urea transporter expression is becoming available, and the possible involvement of aberrant regulation of these transporters in pathological conditions, or as a result of certain pharmacological treatments, has emerged from recent studies.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalPflugers Archiv European Journal of Physiology
Volume450
Issue number4
DOIs
StatePublished - Jul 2005

Fingerprint

Kidney
Facilitated Diffusion
Forensic Anthropology
Gene encoding
Physiology
Knockout Mice
Blood Vessels
Urea
Rodentia
urea transporter
Urine
Pharmacology
Genes

Keywords

  • Kidney
  • Nitrogen
  • Urea transport
  • Urine concentration

ASJC Scopus subject areas

  • Physiology

Cite this

Role and regulation of urea transporters. / Bagnasco, Serena M.

In: Pflugers Archiv European Journal of Physiology, Vol. 450, No. 4, 07.2005, p. 217-226.

Research output: Contribution to journalArticle

@article{0733f9120ea945ae921b5c9e82618d9b,
title = "Role and regulation of urea transporters",
abstract = "In the past few years, significant knowledge has been gained about the physiological role and regulation of urea transporters, which have been now cloned in many species. The two major mammalian urea transporters, UT-A and UT-B, have been best studied in the kidney, where they mediate the facilitated diffusion of urea across tubular, interstitial, and vascular compartments, necessary to maintain an osmolar gradient along the renal corticomedullary axis. The genes encoding these transporters, Slc14A2 for UT-A and Slc14A1 for UT-B, have been characterized in rodents and humans, allowing identification of transcriptional mechanisms involved in the regulation of UT-A expression. The crucial role that urea transporters play in renal physiology is underscored by the phenotypic characteristics of UT-A and UT-B knockout mice, in which lack of specific urea transporters impairs the ability to concentrate urine. Expression of the UT-A and UT-B transporters has also been identified in extra-renal sites, where their physiological significance is only beginning to be elucidated. More information on the mechanisms modulating urea transporter expression is becoming available, and the possible involvement of aberrant regulation of these transporters in pathological conditions, or as a result of certain pharmacological treatments, has emerged from recent studies.",
keywords = "Kidney, Nitrogen, Urea transport, Urine concentration",
author = "Bagnasco, {Serena M}",
year = "2005",
month = "7",
doi = "10.1007/s00424-005-1403-9",
language = "English (US)",
volume = "450",
pages = "217--226",
journal = "Pflugers Archiv European Journal of Physiology",
issn = "0031-6768",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Role and regulation of urea transporters

AU - Bagnasco, Serena M

PY - 2005/7

Y1 - 2005/7

N2 - In the past few years, significant knowledge has been gained about the physiological role and regulation of urea transporters, which have been now cloned in many species. The two major mammalian urea transporters, UT-A and UT-B, have been best studied in the kidney, where they mediate the facilitated diffusion of urea across tubular, interstitial, and vascular compartments, necessary to maintain an osmolar gradient along the renal corticomedullary axis. The genes encoding these transporters, Slc14A2 for UT-A and Slc14A1 for UT-B, have been characterized in rodents and humans, allowing identification of transcriptional mechanisms involved in the regulation of UT-A expression. The crucial role that urea transporters play in renal physiology is underscored by the phenotypic characteristics of UT-A and UT-B knockout mice, in which lack of specific urea transporters impairs the ability to concentrate urine. Expression of the UT-A and UT-B transporters has also been identified in extra-renal sites, where their physiological significance is only beginning to be elucidated. More information on the mechanisms modulating urea transporter expression is becoming available, and the possible involvement of aberrant regulation of these transporters in pathological conditions, or as a result of certain pharmacological treatments, has emerged from recent studies.

AB - In the past few years, significant knowledge has been gained about the physiological role and regulation of urea transporters, which have been now cloned in many species. The two major mammalian urea transporters, UT-A and UT-B, have been best studied in the kidney, where they mediate the facilitated diffusion of urea across tubular, interstitial, and vascular compartments, necessary to maintain an osmolar gradient along the renal corticomedullary axis. The genes encoding these transporters, Slc14A2 for UT-A and Slc14A1 for UT-B, have been characterized in rodents and humans, allowing identification of transcriptional mechanisms involved in the regulation of UT-A expression. The crucial role that urea transporters play in renal physiology is underscored by the phenotypic characteristics of UT-A and UT-B knockout mice, in which lack of specific urea transporters impairs the ability to concentrate urine. Expression of the UT-A and UT-B transporters has also been identified in extra-renal sites, where their physiological significance is only beginning to be elucidated. More information on the mechanisms modulating urea transporter expression is becoming available, and the possible involvement of aberrant regulation of these transporters in pathological conditions, or as a result of certain pharmacological treatments, has emerged from recent studies.

KW - Kidney

KW - Nitrogen

KW - Urea transport

KW - Urine concentration

UR - http://www.scopus.com/inward/record.url?scp=22044452680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22044452680&partnerID=8YFLogxK

U2 - 10.1007/s00424-005-1403-9

DO - 10.1007/s00424-005-1403-9

M3 - Article

C2 - 15924241

AN - SCOPUS:22044452680

VL - 450

SP - 217

EP - 226

JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

SN - 0031-6768

IS - 4

ER -