TY - JOUR
T1 - Role and expression of colony stimulating factor-1 and steel factor receptors and their ligands during pregnancy in the mouse
AU - Arceci, Robert J.
AU - Pampfer, Serge
AU - Pollard, Jeffrey W.
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health GM38156 (R.J.A.); HD25076 (J.W.P.); H.D. 27322 (R.J.A., J.W.P.) and the Albert Einstein Core Cancer Grant P30-CA1330. S.P. was supported in part by a NATO post-doctoral fellowship.
PY - 1992
Y1 - 1992
N2 - It is becoming apparent that the effects of female sex steroid hormones can be mediated by locally synthesized polypeptide growth factors in the uterus. In this paper we describe the patterns of expression of two such growth factors, steel factor and colony stimulating factor-1 (CSF-1), and their transmembrane tyrosine kinase receptors, the products of the c-kit and c-fms proto-oncogenes respectively. Both these uterine synthesized cytokines are directed to uterine hematopoietic cells, the preimplantation embryo and to the extra-embryonic tissues during the postimplantation period. Studies with the CSF-1-deficient osteopetrotic (op/op) mouse show that CSF-1 has important roles during embryonic development and in the regulation of uterine macrophages. These studies establish that CSF-1, whose sex steroid hormone-induced synthesis is restricted to the uterine epithelium, has a paracrine action on embryos as well as being a mediator of epithelial-mesenchymal interactions.
AB - It is becoming apparent that the effects of female sex steroid hormones can be mediated by locally synthesized polypeptide growth factors in the uterus. In this paper we describe the patterns of expression of two such growth factors, steel factor and colony stimulating factor-1 (CSF-1), and their transmembrane tyrosine kinase receptors, the products of the c-kit and c-fms proto-oncogenes respectively. Both these uterine synthesized cytokines are directed to uterine hematopoietic cells, the preimplantation embryo and to the extra-embryonic tissues during the postimplantation period. Studies with the CSF-1-deficient osteopetrotic (op/op) mouse show that CSF-1 has important roles during embryonic development and in the regulation of uterine macrophages. These studies establish that CSF-1, whose sex steroid hormone-induced synthesis is restricted to the uterine epithelium, has a paracrine action on embryos as well as being a mediator of epithelial-mesenchymal interactions.
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U2 - 10.1071/RD9920619
DO - 10.1071/RD9920619
M3 - Article
AN - SCOPUS:84971037651
SN - 1031-3613
VL - 4
SP - 619
EP - 632
JO - Reproduction, Fertility and Development
JF - Reproduction, Fertility and Development
IS - 6
ER -