Role and expression of colony stimulating factor-1 and steel factor receptors and their ligands during pregnancy in the mouse

Robert J. Arceci, Serge Pampfer, Jeffrey W. Pollard

Research output: Contribution to journalArticle

Abstract

It is becoming apparent that the effects of female sex steroid hormones can be mediated by locally synthesized polypeptide growth factors in the uterus. In this paper we describe the patterns of expression of two such growth factors, steel factor and colony stimulating factor-1 (CSF-1), and their transmembrane tyrosine kinase receptors, the products of the c-kit and c-fms proto-oncogenes respectively. Both these uterine synthesized cytokines are directed to uterine hematopoietic cells, the preimplantation embryo and to the extra-embryonic tissues during the postimplantation period. Studies with the CSF-1-deficient osteopetrotic (op/op) mouse show that CSF-1 has important roles during embryonic development and in the regulation of uterine macrophages. These studies establish that CSF-1, whose sex steroid hormone-induced synthesis is restricted to the uterine epithelium, has a paracrine action on embryos as well as being a mediator of epithelial-mesenchymal interactions.

Original languageEnglish (US)
Pages (from-to)619-632
Number of pages14
JournalReproduction, Fertility and Development
Volume4
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

macrophage colony-stimulating factor
Stem Cell Factor
Macrophage Colony-Stimulating Factor
steel
pregnancy
Ligands
Pregnancy
receptors
sex hormones
mice
Gonadal Steroid Hormones
steroid hormones
growth factors
Intercellular Signaling Peptides and Proteins
fms Genes
embryo (animal)
proto-oncogenes
Receptor Protein-Tyrosine Kinases
Blastocyst
uterus

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Developmental Biology
  • Genetics
  • Biotechnology
  • Molecular Biology
  • Endocrinology
  • Reproductive Medicine

Cite this

Role and expression of colony stimulating factor-1 and steel factor receptors and their ligands during pregnancy in the mouse. / Arceci, Robert J.; Pampfer, Serge; Pollard, Jeffrey W.

In: Reproduction, Fertility and Development, Vol. 4, No. 6, 1992, p. 619-632.

Research output: Contribution to journalArticle

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