Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing Sarcoma of bone

S. K. Shirley, L. A. Gilula, G. P. Siegal, M. A. Foulkes, J. M. Kissane, Frederic B Askin

Research output: Contribution to journalArticle

Abstract

Roentgenographic review of the first 210 cases of Ewing sarcoma (ES) in the Intergroup Ewing Sarcoma study revealed that 37.6% of cases had evidence of diffusely increased intraosseous density or diffuse sclerosis (DS). In these cases the sclerosis was usually mixed with various patterns of lysis and/or combined with a periosteal reaction. A radiograph blinded histologic review of selected biopsies showed an 83% incidence of dead bone compared to 23% in those without DS. Ten percent of the cases with DS had appositional new bone formation on dead bone whereas none of the cases without DS showed such reactions. Pathologic explanation of the roentgenographically identified diffuse sclerosis in ES has not been previously well documented in the medical literature.

Original languageEnglish (US)
Pages (from-to)69-78
Number of pages10
JournalSkeletal Radiology
Volume12
Issue number2
DOIs
StatePublished - Jul 1984
Externally publishedYes

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Ewing's Sarcoma
Sclerosis
Bone and Bones
Osteogenesis
Biopsy
Incidence

Keywords

  • Bone
  • Ewing sarcoma
  • Sclerosis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Shirley, S. K., Gilula, L. A., Siegal, G. P., Foulkes, M. A., Kissane, J. M., & Askin, F. B. (1984). Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing Sarcoma of bone. Skeletal Radiology, 12(2), 69-78. https://doi.org/10.1007/BF00360810

Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing Sarcoma of bone. / Shirley, S. K.; Gilula, L. A.; Siegal, G. P.; Foulkes, M. A.; Kissane, J. M.; Askin, Frederic B.

In: Skeletal Radiology, Vol. 12, No. 2, 07.1984, p. 69-78.

Research output: Contribution to journalArticle

Shirley, SK, Gilula, LA, Siegal, GP, Foulkes, MA, Kissane, JM & Askin, FB 1984, 'Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing Sarcoma of bone', Skeletal Radiology, vol. 12, no. 2, pp. 69-78. https://doi.org/10.1007/BF00360810
Shirley, S. K. ; Gilula, L. A. ; Siegal, G. P. ; Foulkes, M. A. ; Kissane, J. M. ; Askin, Frederic B. / Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing Sarcoma of bone. In: Skeletal Radiology. 1984 ; Vol. 12, No. 2. pp. 69-78.
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