Rodents as genetic models of obesity

Yumi Imai; Rexford S. Ahima

doi:10.1016/j.ddmod.2005.08.005

Rodents as genetic models of obesity

Yumi Imai, Rexford S. Ahima

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

There is a high demand for effective pharmacotherapy against obesity as its prevalence increases worldwide. Rodent models have advanced our knowledge of energy homeostasis and are widely used for obesity research. This review describes rodent models of obesity involving spontaneous mutations, knockout or overexpression of genes involved in energy balance and dietary intervention in polygenic rodents. Understanding of the characteristics of these models will facilitate development of therapies for obesity and related diseases.

Original language	English (US)
Pages (from-to)	165-175
Number of pages	11
Journal	Drug Discovery Today: Disease Models
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.ddmod.2005.08.005
State	Published - 2005
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

Access to Document

10.1016/j.ddmod.2005.08.005

Cite this

@article{5b399732e2264cd9b488588c4cf4876c,

title = "Rodents as genetic models of obesity",

abstract = "There is a high demand for effective pharmacotherapy against obesity as its prevalence increases worldwide. Rodent models have advanced our knowledge of energy homeostasis and are widely used for obesity research. This review describes rodent models of obesity involving spontaneous mutations, knockout or overexpression of genes involved in energy balance and dietary intervention in polygenic rodents. Understanding of the characteristics of these models will facilitate development of therapies for obesity and related diseases.",

author = "Yumi Imai and Ahima, {Rexford S.}",

note = "Funding Information: This work was supported by grant PO1-DK49210 from the National Institutes of Health. Yumi Imai was supported by training grant T32-DK07314-22 from the National Institutes of Health.",

year = "2005",

doi = "10.1016/j.ddmod.2005.08.005",

language = "English (US)",

volume = "2",

pages = "165--175",

journal = "Drug Discovery Today: Disease Models",

issn = "1740-6757",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Rodents as genetic models of obesity

AU - Imai, Yumi

AU - Ahima, Rexford S.

N1 - Funding Information: This work was supported by grant PO1-DK49210 from the National Institutes of Health. Yumi Imai was supported by training grant T32-DK07314-22 from the National Institutes of Health.

PY - 2005

Y1 - 2005

N2 - There is a high demand for effective pharmacotherapy against obesity as its prevalence increases worldwide. Rodent models have advanced our knowledge of energy homeostasis and are widely used for obesity research. This review describes rodent models of obesity involving spontaneous mutations, knockout or overexpression of genes involved in energy balance and dietary intervention in polygenic rodents. Understanding of the characteristics of these models will facilitate development of therapies for obesity and related diseases.

AB - There is a high demand for effective pharmacotherapy against obesity as its prevalence increases worldwide. Rodent models have advanced our knowledge of energy homeostasis and are widely used for obesity research. This review describes rodent models of obesity involving spontaneous mutations, knockout or overexpression of genes involved in energy balance and dietary intervention in polygenic rodents. Understanding of the characteristics of these models will facilitate development of therapies for obesity and related diseases.

UR - http://www.scopus.com/inward/record.url?scp=26944480761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26944480761&partnerID=8YFLogxK

U2 - 10.1016/j.ddmod.2005.08.005

DO - 10.1016/j.ddmod.2005.08.005

M3 - Review article

AN - SCOPUS:26944480761

SN - 1740-6757

VL - 2

SP - 165

EP - 175

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

IS - 3

ER -

Rodents as genetic models of obesity

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this