Rodents as genetic models of obesity

Yumi Imai, Rexford S Ahima

Research output: Contribution to journalReview article

Abstract

There is a high demand for effective pharmacotherapy against obesity as its prevalence increases worldwide. Rodent models have advanced our knowledge of energy homeostasis and are widely used for obesity research. This review describes rodent models of obesity involving spontaneous mutations, knockout or overexpression of genes involved in energy balance and dietary intervention in polygenic rodents. Understanding of the characteristics of these models will facilitate development of therapies for obesity and related diseases.

Original languageEnglish (US)
Pages (from-to)165-175
Number of pages11
JournalDrug Discovery Today: Disease Models
Volume2
Issue number3
DOIs
StatePublished - 2005
Externally publishedYes

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Genetic Models
Rodentia
Obesity
Homeostasis
Drug Therapy
Mutation
Research
Genes
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Rodents as genetic models of obesity. / Imai, Yumi; Ahima, Rexford S.

In: Drug Discovery Today: Disease Models, Vol. 2, No. 3, 2005, p. 165-175.

Research output: Contribution to journalReview article

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