Rodent models of glaucoma

Thomas Johnson, Stanislav I. Tomarev

Research output: Contribution to journalReview article

Abstract

Glaucoma is a progressive, age-related optic neuropathy and a leading cause of irreversible blindness in the world. Animal models of glaucoma are essential to our continued efforts of elucidating the natural course of the disease and to developing therapeutic interventions to halt or reverse the progression of the condition. Over the past 10-15 years, rodents have become a popular model organism to study glaucoma, because of their high degree of availability, relatively low cost, short life-span, and amenability to experimental and genetic manipulation. In this review, we examine the numerous in vivo and in vitro rodent models of glaucoma, discuss the methods used to generate them, summarize some of the major findings obtained in these models, and identify individual strengths and weaknesses for the various systems.

Original languageEnglish (US)
Pages (from-to)349-358
Number of pages10
JournalBrain Research Bulletin
Volume81
Issue number2-3
DOIs
StatePublished - Feb 15 2010
Externally publishedYes

Fingerprint

Glaucoma
Rodentia
Optic Nerve Diseases
Blindness
Animal Models
Costs and Cost Analysis
Therapeutics

Keywords

  • Animal models
  • Glaucoma
  • Intraocular pressure
  • Myocilin
  • Retina
  • Retinal ganglion cells
  • Rodent models

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rodent models of glaucoma. / Johnson, Thomas; Tomarev, Stanislav I.

In: Brain Research Bulletin, Vol. 81, No. 2-3, 15.02.2010, p. 349-358.

Research output: Contribution to journalReview article

Johnson, Thomas ; Tomarev, Stanislav I. / Rodent models of glaucoma. In: Brain Research Bulletin. 2010 ; Vol. 81, No. 2-3. pp. 349-358.
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