Rodent IgE-binding factor genes are members of an endogenous, retrovirus-like gene family

K. W. Moore, P. Jardieu, J. A. Mietz, M. L. Trounstine, E. L. Kuff, K. Ishizaka, C. L. Martens

Research output: Contribution to journalArticlepeer-review

Abstract

Synthesis of IgE by B lymphocytes can be regulated by soluble lymphocyte factors which have affinity for the Fc region of IgE (IgE-binding factors). In previous studies, we identified cDNA clones encoding rodent IgE-binding factors by direct expression in transfected mammalian cells. Here we show that IgE-binding factor cDNA clone 8.3 is a member of the endogenous, retrovirus-like intracisternal A-particle gene family of the mouse. This conclusion is supported by blot hybridization. DNA sequence comparisons, heteroduplex analysis, and immunochemical cross-reactivity of the encoded proteins. The results identify a member of this highly reiterated gene family with a role in regulation of the allergic immune response.

Original languageEnglish (US)
Pages (from-to)4283-4290
Number of pages8
JournalJournal of Immunology
Volume136
Issue number11
StatePublished - 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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